Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers

The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including...

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Autores principales: Nguyen, Martin V., Loof, Lydia, Falchook, Gerald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208386/
https://www.ncbi.nlm.nih.gov/pubmed/35756176
http://dx.doi.org/10.4103/JIPO.JIPO_2_20
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author Nguyen, Martin V.
Loof, Lydia
Falchook, Gerald S.
author_facet Nguyen, Martin V.
Loof, Lydia
Falchook, Gerald S.
author_sort Nguyen, Martin V.
collection PubMed
description The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers.
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spelling pubmed-92083862022-06-23 Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers Nguyen, Martin V. Loof, Lydia Falchook, Gerald S. J Immunother Precis Oncol Review Articles The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein. BET protein alterations are associated with some solid tumor cancers, including nuclear protein in testis midline carcinoma. BET protein has a role in carcinogenesis and in the regulation of the cell cycle. A number of BET inhibitors have entered clinical trials. This review discusses the results of BET inhibitor clinical trials in solid tumor cancers. Wolters Kluwer - Medknow 2020-02-05 /pmc/articles/PMC9208386/ /pubmed/35756176 http://dx.doi.org/10.4103/JIPO.JIPO_2_20 Text en © 2020 Journal of Immunotherapy and Precision Oncology | Published by Wolters Kluwer - Medknow https://creativecommons.org/licenses/by/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License (https://creativecommons.org/licenses/by/4.0/) , which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Articles
Nguyen, Martin V.
Loof, Lydia
Falchook, Gerald S.
Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title_full Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title_fullStr Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title_full_unstemmed Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title_short Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
title_sort bromodomain and extra-terminal (bet) domain protein inhibitors for solid tumor cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208386/
https://www.ncbi.nlm.nih.gov/pubmed/35756176
http://dx.doi.org/10.4103/JIPO.JIPO_2_20
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