Montelukast ameliorated pemetrexed-induced cytotoxicity in hepatocytes by mitigating endoplasmic reticulum (ER) stress and nucleotide oligomerization domain-like receptor protein 3 (NLRP3) activation

Pemetrexed (PEM) is an effective chemotherapeutic drug used for the treatment of clinical non-small-cell lung cancer (NSCLC) and is reported to induce severe hepatotoxicity. Exploring potential drugs which could counteract the side effects of PEM is of great clinical interest. Here, we aim to examin...

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Detalles Bibliográficos
Autores principales: Fei, Zhengdong, Zhang, Lu, Wang, Lei, Jiang, Hui, Peng, Aiqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208499/
https://www.ncbi.nlm.nih.gov/pubmed/35291928
http://dx.doi.org/10.1080/21655979.2022.2051689

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