The role of long non-coding RNA FGD5-AS1 in cancer

Long noncoding RNAs (lncRNAs) refers to a class of RNAs that have at least 200 nucleotides and do not encode proteins, and the relationship between lncRNA and cancer has recently attracted considerable research attention. The lncRNA FGD5-AS1 is a newly discovered lncRNA with a length of 3772 nucleot...

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Autores principales: He, Na, Xiang, Linbiao, Chen, Lei, Tong, Haobin, Wang, Keshen, Zhao, Jie, Song, Feixue, Yang, Hanteng, Wei, Xinyuan, Jiao, Zuoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208527/
https://www.ncbi.nlm.nih.gov/pubmed/35475392
http://dx.doi.org/10.1080/21655979.2022.2067292
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author He, Na
Xiang, Linbiao
Chen, Lei
Tong, Haobin
Wang, Keshen
Zhao, Jie
Song, Feixue
Yang, Hanteng
Wei, Xinyuan
Jiao, Zuoyi
author_facet He, Na
Xiang, Linbiao
Chen, Lei
Tong, Haobin
Wang, Keshen
Zhao, Jie
Song, Feixue
Yang, Hanteng
Wei, Xinyuan
Jiao, Zuoyi
author_sort He, Na
collection PubMed
description Long noncoding RNAs (lncRNAs) refers to a class of RNAs that have at least 200 nucleotides and do not encode proteins, and the relationship between lncRNA and cancer has recently attracted considerable research attention. The lncRNA FGD5-AS1 is a newly discovered lncRNA with a length of 3772 nucleotides. Studies have found that FGD5-AS1 is abnormally highly expressed in many cancer tissues and was closely related to the lymph node metastasis, tumor invasion, survival time, and recurrence rate of various cancers. Mechanistic analyses show that FGD5-AS1 can stabilize mRNA expression by sponging miRNA, which not only induces cancer cell proliferation, metastasis, invasion, and chemoresistance in vitro, but also promotes tumor growth and metastasis in vivo. In addition, FGD5-AS1 can serve as a diagnostic or prognostic marker for a variety of cancers. This review demonstrates the clinical significance of FGD5-AS1 in human cancer and its role in tumorigenesis and tumor progression.
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spelling pubmed-92085272022-06-21 The role of long non-coding RNA FGD5-AS1 in cancer He, Na Xiang, Linbiao Chen, Lei Tong, Haobin Wang, Keshen Zhao, Jie Song, Feixue Yang, Hanteng Wei, Xinyuan Jiao, Zuoyi Bioengineered Review Long noncoding RNAs (lncRNAs) refers to a class of RNAs that have at least 200 nucleotides and do not encode proteins, and the relationship between lncRNA and cancer has recently attracted considerable research attention. The lncRNA FGD5-AS1 is a newly discovered lncRNA with a length of 3772 nucleotides. Studies have found that FGD5-AS1 is abnormally highly expressed in many cancer tissues and was closely related to the lymph node metastasis, tumor invasion, survival time, and recurrence rate of various cancers. Mechanistic analyses show that FGD5-AS1 can stabilize mRNA expression by sponging miRNA, which not only induces cancer cell proliferation, metastasis, invasion, and chemoresistance in vitro, but also promotes tumor growth and metastasis in vivo. In addition, FGD5-AS1 can serve as a diagnostic or prognostic marker for a variety of cancers. This review demonstrates the clinical significance of FGD5-AS1 in human cancer and its role in tumorigenesis and tumor progression. Taylor & Francis 2022-04-27 /pmc/articles/PMC9208527/ /pubmed/35475392 http://dx.doi.org/10.1080/21655979.2022.2067292 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
He, Na
Xiang, Linbiao
Chen, Lei
Tong, Haobin
Wang, Keshen
Zhao, Jie
Song, Feixue
Yang, Hanteng
Wei, Xinyuan
Jiao, Zuoyi
The role of long non-coding RNA FGD5-AS1 in cancer
title The role of long non-coding RNA FGD5-AS1 in cancer
title_full The role of long non-coding RNA FGD5-AS1 in cancer
title_fullStr The role of long non-coding RNA FGD5-AS1 in cancer
title_full_unstemmed The role of long non-coding RNA FGD5-AS1 in cancer
title_short The role of long non-coding RNA FGD5-AS1 in cancer
title_sort role of long non-coding rna fgd5-as1 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208527/
https://www.ncbi.nlm.nih.gov/pubmed/35475392
http://dx.doi.org/10.1080/21655979.2022.2067292
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