Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an attractive prospect of the cell-replacement therapy for Parkinson’s disease (PD). However, it is unclear whether repressing polypyrimidine tract binding protein 1 (PTBP1) could efficiently convert astrocyte to DAns in...

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Detalles Bibliográficos
Autores principales: Chen, Weizhao, Zheng, Qiongping, Huang, Qiaoying, Ma, Shanshan, Li, Mingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208759/
https://www.ncbi.nlm.nih.gov/pubmed/35535997
http://dx.doi.org/10.7554/eLife.75636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208759/
https://www.ncbi.nlm.nih.gov/pubmed/35535997
http://dx.doi.org/10.7554/eLife.75636

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