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Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an attractive prospect of the cell-replacement therapy for Parkinson’s disease (PD). However, it is unclear whether repressing polypyrimidine tract binding protein 1 (PTBP1) could efficiently convert astrocyte to DAns in...

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Detalles Bibliográficos
Autores principales:	Chen, Weizhao, Zheng, Qiongping, Huang, Qiaoying, Ma, Shanshan, Li, Mingtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208759/ https://www.ncbi.nlm.nih.gov/pubmed/35535997 http://dx.doi.org/10.7554/eLife.75636

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