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How does flecainide impact RyR2 channel function?

Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (Na(V)1.5), has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) release. It has been introduced as a clinical antiarrhythmic agent for catecholaminergic polymorphi...

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Detalles Bibliográficos
Autores principales:	Salvage, Samantha C., Huang, Christopher L.-H., Fraser, James A., Dulhunty, Angela F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Viewpoint
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208819/ https://www.ncbi.nlm.nih.gov/pubmed/35713932 http://dx.doi.org/10.1085/jgp.202213089

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