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323 Generation of a functional precision medicine pipeline which combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for glioblastoma

OBJECTIVES/GOALS: A functional precision medicine platform to identify therapeutic targets for a glioblastoma patient with Li Fraumeni syndrome was performed. Comparative transcriptomics identified druggable targets and patient derived organoids and a 3D-PREDICT drug screening assay was used to vali...

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Detalles Bibliográficos
Autores principales:	Reed, Megan R., Lyle, A. Geoffrey, De Loose, Annick, Learned, Katrina, Vibat, Cecile Rose T., Wardell, Christopher P., Eoff, Robert L., Vaske, Olena M., Rodriguez, Analiz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2022
Materias:	Valued Approaches
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209040/ http://dx.doi.org/10.1017/cts.2022.180

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