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Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017

BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV...

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Autores principales: Song, Ji-Hun, Kim, Hyoung-Ryoul, Lee, Dong-Wook, Min, Jeehee, Lee, Yu Min, Kang, Mo-Yeol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Occupational & Environmental Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209099/
https://www.ncbi.nlm.nih.gov/pubmed/35801225
http://dx.doi.org/10.35371/aoem.2022.34.e9
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author Song, Ji-Hun
Kim, Hyoung-Ryoul
Lee, Dong-Wook
Min, Jeehee
Lee, Yu Min
Kang, Mo-Yeol
author_facet Song, Ji-Hun
Kim, Hyoung-Ryoul
Lee, Dong-Wook
Min, Jeehee
Lee, Yu Min
Kang, Mo-Yeol
author_sort Song, Ji-Hun
collection PubMed
description BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV–VII. For the final 15,316 study participant, the information on working hours was obtained through questionnaires, and liver enzyme levels, consisting of serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), through blood tests. The relationship between weekly working hours and abnormal levels of liver enzymes was analyzed using multiple logistic regression, and a trend test was also conducted. RESULTS: In male, working ≥ 61 hours per week was significantly associated with elevated AST and ALT levels compared with working 35–52 hours per week. Even after adjusting for covariates, the odds ratios (ORs) of abnormal AST and ALT increased by 1.51 (95% confidence interval: 1.20–2.05) and 1.25 (1.03–1.52), respectively, and a dose-response relationship was observed. This association was more prominent among the high-risk group, such as those aged > 40 years, obese individuals, worker on non-standard work schedule, pink-collar workers, or temporary worker. No correlation was observed in female. CONCLUSIONS: Long working hours are associated with abnormal liver function test results in male. Strict adherence to statutory working hours is necessary to protect workers’ liver health.
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spelling pubmed-92090992022-07-06 Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 Song, Ji-Hun Kim, Hyoung-Ryoul Lee, Dong-Wook Min, Jeehee Lee, Yu Min Kang, Mo-Yeol Ann Occup Environ Med Original Article BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV–VII. For the final 15,316 study participant, the information on working hours was obtained through questionnaires, and liver enzyme levels, consisting of serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), through blood tests. The relationship between weekly working hours and abnormal levels of liver enzymes was analyzed using multiple logistic regression, and a trend test was also conducted. RESULTS: In male, working ≥ 61 hours per week was significantly associated with elevated AST and ALT levels compared with working 35–52 hours per week. Even after adjusting for covariates, the odds ratios (ORs) of abnormal AST and ALT increased by 1.51 (95% confidence interval: 1.20–2.05) and 1.25 (1.03–1.52), respectively, and a dose-response relationship was observed. This association was more prominent among the high-risk group, such as those aged > 40 years, obese individuals, worker on non-standard work schedule, pink-collar workers, or temporary worker. No correlation was observed in female. CONCLUSIONS: Long working hours are associated with abnormal liver function test results in male. Strict adherence to statutory working hours is necessary to protect workers’ liver health. Korean Society of Occupational & Environmental Medicine 2022-05-13 /pmc/articles/PMC9209099/ /pubmed/35801225 http://dx.doi.org/10.35371/aoem.2022.34.e9 Text en Copyright © 2022 Korean Society of Occupational & Environmental Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Ji-Hun
Kim, Hyoung-Ryoul
Lee, Dong-Wook
Min, Jeehee
Lee, Yu Min
Kang, Mo-Yeol
Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title_full Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title_fullStr Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title_full_unstemmed Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title_short Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
title_sort association between long working hours and liver enzymes: evidence from the korea national health and nutrition examination survey, 2007–2017
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209099/
https://www.ncbi.nlm.nih.gov/pubmed/35801225
http://dx.doi.org/10.35371/aoem.2022.34.e9
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