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Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017
BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Occupational & Environmental Medicine
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209099/ https://www.ncbi.nlm.nih.gov/pubmed/35801225 http://dx.doi.org/10.35371/aoem.2022.34.e9 |
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author | Song, Ji-Hun Kim, Hyoung-Ryoul Lee, Dong-Wook Min, Jeehee Lee, Yu Min Kang, Mo-Yeol |
author_facet | Song, Ji-Hun Kim, Hyoung-Ryoul Lee, Dong-Wook Min, Jeehee Lee, Yu Min Kang, Mo-Yeol |
author_sort | Song, Ji-Hun |
collection | PubMed |
description | BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV–VII. For the final 15,316 study participant, the information on working hours was obtained through questionnaires, and liver enzyme levels, consisting of serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), through blood tests. The relationship between weekly working hours and abnormal levels of liver enzymes was analyzed using multiple logistic regression, and a trend test was also conducted. RESULTS: In male, working ≥ 61 hours per week was significantly associated with elevated AST and ALT levels compared with working 35–52 hours per week. Even after adjusting for covariates, the odds ratios (ORs) of abnormal AST and ALT increased by 1.51 (95% confidence interval: 1.20–2.05) and 1.25 (1.03–1.52), respectively, and a dose-response relationship was observed. This association was more prominent among the high-risk group, such as those aged > 40 years, obese individuals, worker on non-standard work schedule, pink-collar workers, or temporary worker. No correlation was observed in female. CONCLUSIONS: Long working hours are associated with abnormal liver function test results in male. Strict adherence to statutory working hours is necessary to protect workers’ liver health. |
format | Online Article Text |
id | pubmed-9209099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society of Occupational & Environmental Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-92090992022-07-06 Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 Song, Ji-Hun Kim, Hyoung-Ryoul Lee, Dong-Wook Min, Jeehee Lee, Yu Min Kang, Mo-Yeol Ann Occup Environ Med Original Article BACKGROUND: Long working hours causes several health risks, but little is known about its effects on the liver. This study aimed to examine the correlation between working hours and abnormal liver enzyme levels. METHODS: We used data from the Korea National Health and Nutrition Examination Survey IV–VII. For the final 15,316 study participant, the information on working hours was obtained through questionnaires, and liver enzyme levels, consisting of serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), through blood tests. The relationship between weekly working hours and abnormal levels of liver enzymes was analyzed using multiple logistic regression, and a trend test was also conducted. RESULTS: In male, working ≥ 61 hours per week was significantly associated with elevated AST and ALT levels compared with working 35–52 hours per week. Even after adjusting for covariates, the odds ratios (ORs) of abnormal AST and ALT increased by 1.51 (95% confidence interval: 1.20–2.05) and 1.25 (1.03–1.52), respectively, and a dose-response relationship was observed. This association was more prominent among the high-risk group, such as those aged > 40 years, obese individuals, worker on non-standard work schedule, pink-collar workers, or temporary worker. No correlation was observed in female. CONCLUSIONS: Long working hours are associated with abnormal liver function test results in male. Strict adherence to statutory working hours is necessary to protect workers’ liver health. Korean Society of Occupational & Environmental Medicine 2022-05-13 /pmc/articles/PMC9209099/ /pubmed/35801225 http://dx.doi.org/10.35371/aoem.2022.34.e9 Text en Copyright © 2022 Korean Society of Occupational & Environmental Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Ji-Hun Kim, Hyoung-Ryoul Lee, Dong-Wook Min, Jeehee Lee, Yu Min Kang, Mo-Yeol Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title | Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title_full | Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title_fullStr | Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title_full_unstemmed | Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title_short | Association between long working hours and liver enzymes: evidence from the Korea National Health and Nutrition Examination Survey, 2007–2017 |
title_sort | association between long working hours and liver enzymes: evidence from the korea national health and nutrition examination survey, 2007–2017 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209099/ https://www.ncbi.nlm.nih.gov/pubmed/35801225 http://dx.doi.org/10.35371/aoem.2022.34.e9 |
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