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434 In silico ADMET optimization and preliminary biologic activity of novel spermine oxidase inhibitors as neuroprotective agents

OBJECTIVES/GOALS: The goal of this project was to conduct a preliminary assessment of in vivo feasibility early on in the drug-discovery process in an effort to expedite the translation of novel drug scaffolds to potential clinical candidates. The data gathered in this study will be used to direct a...

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Detalles Bibliográficos
Autores principales:	Furbish, Amelia B, Burger, Pieter, Peterson, Yuri K, Woster, Patrick M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2022
Materias:	Valued Approaches
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209296/ http://dx.doi.org/10.1017/cts.2022.252

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