SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

Mutations or deletions of the SHANK3 gene are causative for Phelan–McDermid syndrome (PMDS), a syndromic form of autism spectrum disorders (ASDs). We analyzed Shank3Δ11(−/−) mice and organoids from PMDS individuals to study effects on myelin. SHANK3 was found to be expressed in oligodendrocytes and...

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Detalles Bibliográficos
Autores principales: Malara, Mariagiovanna, Lutz, Anne-Kathrin, Incearap, Berra, Bauer, Helen Friedericke, Cursano, Silvia, Volbracht, Katrin, Lerner, Joanna Janina, Pandey, Rakshita, Delling, Jan Philipp, Ioannidis, Valentin, Arévalo, Andrea Pérez, von Bernhardi, Jaime Eugenin, Schön, Michael, Bockmann, Jürgen, Dimou, Leda, Boeckers, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209365/
https://www.ncbi.nlm.nih.gov/pubmed/35726031
http://dx.doi.org/10.1007/s00018-022-04400-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209365/
https://www.ncbi.nlm.nih.gov/pubmed/35726031
http://dx.doi.org/10.1007/s00018-022-04400-4

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