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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT(1)-fragment domains in cardiomyocytes

Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca(2+) release units required for excitation-contraction coupling in cardiomyocytes. While down...

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Detalles Bibliográficos
Autores principales:	Weninger, Gunnar, Pochechueva, Tatiana, El Chami, Dana, Luo, Xiaojing, Kohl, Tobias, Brandenburg, Sören, Urlaub, Henning, Guan, Kaomei, Lenz, Christof, Lehnart, Stephan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209451/ https://www.ncbi.nlm.nih.gov/pubmed/35725601 http://dx.doi.org/10.1038/s41598-022-14320-9

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