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Artificial intelligence guided conformational mining of intrinsically disordered proteins

Artificial intelligence recently achieved the breakthrough of predicting the three-dimensional structures of proteins. The next frontier is presented by intrinsically disordered proteins (IDPs), which, representing 30% to 50% of proteomes, readily access vast conformational space. Molecular dynamics...

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Detalles Bibliográficos
Autores principales: Gupta, Aayush, Dey, Souvik, Hicks, Alan, Zhou, Huan-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209487/
https://www.ncbi.nlm.nih.gov/pubmed/35725761
http://dx.doi.org/10.1038/s42003-022-03562-y