Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion

16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency...

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Autores principales: Madencioglu, Deniz A., Kruth, Karina, Shin, Mallory, Andreasen, Nancy, Wassink, Thomas, Williams, Aislinn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209596/
https://www.ncbi.nlm.nih.gov/pubmed/34953327
http://dx.doi.org/10.1016/j.scr.2021.102636
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author Madencioglu, Deniz A.
Kruth, Karina
Shin, Mallory
Andreasen, Nancy
Wassink, Thomas
Williams, Aislinn
author_facet Madencioglu, Deniz A.
Kruth, Karina
Shin, Mallory
Andreasen, Nancy
Wassink, Thomas
Williams, Aislinn
author_sort Madencioglu, Deniz A.
collection PubMed
description 16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.
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spelling pubmed-92095962023-06-21 Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion Madencioglu, Deniz A. Kruth, Karina Shin, Mallory Andreasen, Nancy Wassink, Thomas Williams, Aislinn Stem Cell Res Article 16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers. 2022-03 2021-12-21 /pmc/articles/PMC9209596/ /pubmed/34953327 http://dx.doi.org/10.1016/j.scr.2021.102636 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Madencioglu, Deniz A.
Kruth, Karina
Shin, Mallory
Andreasen, Nancy
Wassink, Thomas
Williams, Aislinn
Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title_full Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title_fullStr Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title_full_unstemmed Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title_short Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
title_sort generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209596/
https://www.ncbi.nlm.nih.gov/pubmed/34953327
http://dx.doi.org/10.1016/j.scr.2021.102636
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