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Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone
BACKGROUND: Langerhans cell sarcoma (LCS) is an extremely rare type of malignant tumor that originates from Langerhans cells (LC). It is characterized by the malignant proliferation and dissemination of LC and is extremely invasive, with rapid progression and a poor prognosis. Treatment includes res...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209640/ https://www.ncbi.nlm.nih.gov/pubmed/35747436 http://dx.doi.org/10.3389/fsurg.2022.882694 |
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author | Xie, Shan Shao, Zhilin Shao, Dongqi Du, Bang Han, Yi Li, Yu Zhang, Binbin Zheng, Xialin Jiang, Zhiquan |
author_facet | Xie, Shan Shao, Zhilin Shao, Dongqi Du, Bang Han, Yi Li, Yu Zhang, Binbin Zheng, Xialin Jiang, Zhiquan |
author_sort | Xie, Shan |
collection | PubMed |
description | BACKGROUND: Langerhans cell sarcoma (LCS) is an extremely rare type of malignant tumor that originates from Langerhans cells (LC). It is characterized by the malignant proliferation and dissemination of LC and is extremely invasive, with rapid progression and a poor prognosis. Treatment includes resection of lesions, radiotherapy, chemotherapy, immunotherapy, and transplantation of hematopoietic stem cells. However, a unified and optimized treatment plan is lacking, and individualized treatment is accepted. CASE PRESENTATION: We report an 18-year-old man with intracranial and extracranial communicative LCS that occurred in only the left forehead without metastasis to other regions. Clinical and hematological data were normal. We undertook complete resection of diseased tissue, which was pathologically examined. Staining (hematoxylin and eosin) showed positivity for cluster of differentiation (CD)1a (++), S-100 protein (++), P53 (++), CD68 (+), cyclin D1 (+), cyclin A (+), cyclin B1 (+), IGF2BP3 (+), and Ki-67 (45%–50%). Recurrence or metastasis were not observed after long-term follow-up. CONCLUSION: LCS is a rare malignant tumor, and one that occurs with intracranial and extracranial communication is even rarer. Active adoption of an individualized treatment plan is crucial. |
format | Online Article Text |
id | pubmed-9209640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92096402022-06-22 Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone Xie, Shan Shao, Zhilin Shao, Dongqi Du, Bang Han, Yi Li, Yu Zhang, Binbin Zheng, Xialin Jiang, Zhiquan Front Surg Surgery BACKGROUND: Langerhans cell sarcoma (LCS) is an extremely rare type of malignant tumor that originates from Langerhans cells (LC). It is characterized by the malignant proliferation and dissemination of LC and is extremely invasive, with rapid progression and a poor prognosis. Treatment includes resection of lesions, radiotherapy, chemotherapy, immunotherapy, and transplantation of hematopoietic stem cells. However, a unified and optimized treatment plan is lacking, and individualized treatment is accepted. CASE PRESENTATION: We report an 18-year-old man with intracranial and extracranial communicative LCS that occurred in only the left forehead without metastasis to other regions. Clinical and hematological data were normal. We undertook complete resection of diseased tissue, which was pathologically examined. Staining (hematoxylin and eosin) showed positivity for cluster of differentiation (CD)1a (++), S-100 protein (++), P53 (++), CD68 (+), cyclin D1 (+), cyclin A (+), cyclin B1 (+), IGF2BP3 (+), and Ki-67 (45%–50%). Recurrence or metastasis were not observed after long-term follow-up. CONCLUSION: LCS is a rare malignant tumor, and one that occurs with intracranial and extracranial communication is even rarer. Active adoption of an individualized treatment plan is crucial. Frontiers Media S.A. 2022-06-07 /pmc/articles/PMC9209640/ /pubmed/35747436 http://dx.doi.org/10.3389/fsurg.2022.882694 Text en Copyright © 2022 Xie, Shao, Shao, Du, Han, Li, Zhang, Zheng and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Xie, Shan Shao, Zhilin Shao, Dongqi Du, Bang Han, Yi Li, Yu Zhang, Binbin Zheng, Xialin Jiang, Zhiquan Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title | Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title_full | Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title_fullStr | Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title_full_unstemmed | Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title_short | Case Report: Langerhans Cell Sarcoma With Intracranial and Extracranial Communication on the Left Frontal Bone |
title_sort | case report: langerhans cell sarcoma with intracranial and extracranial communication on the left frontal bone |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209640/ https://www.ncbi.nlm.nih.gov/pubmed/35747436 http://dx.doi.org/10.3389/fsurg.2022.882694 |
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