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Manipulating the neonatal gut microbiome: current understanding and future perspectives

The development of a healthy intestinal microbiome following birth contributes to the overall health of the infant during childhood and into adulthood. However, modern birth practices such as caesarean delivery, feeding, antibiotic exposure as well as maternal factors have the potential to greatly i...

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Detalles Bibliográficos
Autores principales: Wong, Emma, Lui, Kei, Day, Andrew S, Leach, Steven T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209688/
https://www.ncbi.nlm.nih.gov/pubmed/34433586
http://dx.doi.org/10.1136/archdischild-2021-321922
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author Wong, Emma
Lui, Kei
Day, Andrew S
Leach, Steven T
author_facet Wong, Emma
Lui, Kei
Day, Andrew S
Leach, Steven T
author_sort Wong, Emma
collection PubMed
description The development of a healthy intestinal microbiome following birth contributes to the overall health of the infant during childhood and into adulthood. However, modern birth practices such as caesarean delivery, feeding, antibiotic exposure as well as maternal factors have the potential to greatly impact infant microbiome development. Aberrant microbiome development may be a key factor in the increasing incidence of inflammatory and gut diseases. This review will summarise the current understanding of how modern birth practices may contribute to deficiencies in neonatal gut microbiome development and will also present potential methods of microbiome engineering that aim to ensure the development of a healthy and robust microbiome to protect the host from disease throughout their life.
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spelling pubmed-92096882022-07-08 Manipulating the neonatal gut microbiome: current understanding and future perspectives Wong, Emma Lui, Kei Day, Andrew S Leach, Steven T Arch Dis Child Fetal Neonatal Ed Review The development of a healthy intestinal microbiome following birth contributes to the overall health of the infant during childhood and into adulthood. However, modern birth practices such as caesarean delivery, feeding, antibiotic exposure as well as maternal factors have the potential to greatly impact infant microbiome development. Aberrant microbiome development may be a key factor in the increasing incidence of inflammatory and gut diseases. This review will summarise the current understanding of how modern birth practices may contribute to deficiencies in neonatal gut microbiome development and will also present potential methods of microbiome engineering that aim to ensure the development of a healthy and robust microbiome to protect the host from disease throughout their life. BMJ Publishing Group 2022-07 2021-08-25 /pmc/articles/PMC9209688/ /pubmed/34433586 http://dx.doi.org/10.1136/archdischild-2021-321922 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Wong, Emma
Lui, Kei
Day, Andrew S
Leach, Steven T
Manipulating the neonatal gut microbiome: current understanding and future perspectives
title Manipulating the neonatal gut microbiome: current understanding and future perspectives
title_full Manipulating the neonatal gut microbiome: current understanding and future perspectives
title_fullStr Manipulating the neonatal gut microbiome: current understanding and future perspectives
title_full_unstemmed Manipulating the neonatal gut microbiome: current understanding and future perspectives
title_short Manipulating the neonatal gut microbiome: current understanding and future perspectives
title_sort manipulating the neonatal gut microbiome: current understanding and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209688/
https://www.ncbi.nlm.nih.gov/pubmed/34433586
http://dx.doi.org/10.1136/archdischild-2021-321922
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