Cargando…

Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis

There are few studies on the prognostic impact of CEA level at the time of recurrence in recurrent colorectal cancer. The objective of this study was to evaluate the prognostic value of serum CEA levels at the time of recurrence in patients with recurrent colorectal cancer. Between 2007 and 2014, 96...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Jung Kyong, Huh, Jung Wook, Lee, Woo Yong, Yun, Seong Hyeon, Kim, Hee Cheol, Cho, Yong Beom, Park, Yoon Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209715/
https://www.ncbi.nlm.nih.gov/pubmed/35747835
http://dx.doi.org/10.3389/fonc.2022.821986
_version_ 1784730006542352384
author Shin, Jung Kyong
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
author_facet Shin, Jung Kyong
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
author_sort Shin, Jung Kyong
collection PubMed
description There are few studies on the prognostic impact of CEA level at the time of recurrence in recurrent colorectal cancer. The objective of this study was to evaluate the prognostic value of serum CEA levels at the time of recurrence in patients with recurrent colorectal cancer. Between 2007 and 2014, 962 consecutive recurrent patients for colorectal cancer were analyzed. These patients were divided into two groups according to CEA level at the time of recurrence (r-CEA): high r-CEA (≥5 ng/ml) (n = 428) and normal r-CEA (<5 ng/ml) (n = 534). The prognostic effects of r-CEA were evaluated by one-to-one propensity score matching (PSM) to adjust factors between groups. After matching, a total of 778 patients, 389 per group, were analyzed. After matching, the 5-year disease-free survival rate for the high r-CEA group was significantly lower than that for the normal r-CEA group. The 5-year overall survival rate was 56.5% in the high r-CEA group and 66.0% in the normal r-CEA group (p = 0.008). The 5-year cancer-specific survival rate was 61.7% in the high group and 67.5% in the normal group (p = 0.035). In a multivariate analysis of prognostic factors, high preoperative CEA level at the time of recurrence, poor histologic grade, and lymphatic invasion were associated with poorer overall survival. The high r-CEA level group showed significantly poorer prognosis than the normal r-CEA group. Therefore, the r-CEA level can be used as a prognostic factor in recurrent colorectal cancer. Aggressive adjuvant treatment needs to be considered for patients with an initially high CEA level and lymph node positivity who are prone to recurrence.
format Online
Article
Text
id pubmed-9209715
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92097152022-06-22 Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis Shin, Jung Kyong Huh, Jung Wook Lee, Woo Yong Yun, Seong Hyeon Kim, Hee Cheol Cho, Yong Beom Park, Yoon Ah Front Oncol Oncology There are few studies on the prognostic impact of CEA level at the time of recurrence in recurrent colorectal cancer. The objective of this study was to evaluate the prognostic value of serum CEA levels at the time of recurrence in patients with recurrent colorectal cancer. Between 2007 and 2014, 962 consecutive recurrent patients for colorectal cancer were analyzed. These patients were divided into two groups according to CEA level at the time of recurrence (r-CEA): high r-CEA (≥5 ng/ml) (n = 428) and normal r-CEA (<5 ng/ml) (n = 534). The prognostic effects of r-CEA were evaluated by one-to-one propensity score matching (PSM) to adjust factors between groups. After matching, a total of 778 patients, 389 per group, were analyzed. After matching, the 5-year disease-free survival rate for the high r-CEA group was significantly lower than that for the normal r-CEA group. The 5-year overall survival rate was 56.5% in the high r-CEA group and 66.0% in the normal r-CEA group (p = 0.008). The 5-year cancer-specific survival rate was 61.7% in the high group and 67.5% in the normal group (p = 0.035). In a multivariate analysis of prognostic factors, high preoperative CEA level at the time of recurrence, poor histologic grade, and lymphatic invasion were associated with poorer overall survival. The high r-CEA level group showed significantly poorer prognosis than the normal r-CEA group. Therefore, the r-CEA level can be used as a prognostic factor in recurrent colorectal cancer. Aggressive adjuvant treatment needs to be considered for patients with an initially high CEA level and lymph node positivity who are prone to recurrence. Frontiers Media S.A. 2022-06-07 /pmc/articles/PMC9209715/ /pubmed/35747835 http://dx.doi.org/10.3389/fonc.2022.821986 Text en Copyright © 2022 Shin, Huh, Lee, Yun, Kim, Cho and Park https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shin, Jung Kyong
Huh, Jung Wook
Lee, Woo Yong
Yun, Seong Hyeon
Kim, Hee Cheol
Cho, Yong Beom
Park, Yoon Ah
Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title_full Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title_fullStr Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title_full_unstemmed Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title_short Elevated Carcinoembryonic Antigen at the Time of Recurrence as a Poor Prognostic Factor in Colorectal Cancer: A Propensity Score Matching Analysis
title_sort elevated carcinoembryonic antigen at the time of recurrence as a poor prognostic factor in colorectal cancer: a propensity score matching analysis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209715/
https://www.ncbi.nlm.nih.gov/pubmed/35747835
http://dx.doi.org/10.3389/fonc.2022.821986
work_keys_str_mv AT shinjungkyong elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT huhjungwook elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT leewooyong elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT yunseonghyeon elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT kimheecheol elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT choyongbeom elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis
AT parkyoonah elevatedcarcinoembryonicantigenatthetimeofrecurrenceasapoorprognosticfactorincolorectalcancerapropensityscorematchinganalysis