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The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examinat...

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Autores principales: Cheng, Tiffany W., Ahern, Madeline C., Giubellino, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209745/
https://www.ncbi.nlm.nih.gov/pubmed/35747831
http://dx.doi.org/10.3389/fonc.2022.889223
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author Cheng, Tiffany W.
Ahern, Madeline C.
Giubellino, Alessio
author_facet Cheng, Tiffany W.
Ahern, Madeline C.
Giubellino, Alessio
author_sort Cheng, Tiffany W.
collection PubMed
description Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions.
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spelling pubmed-92097452022-06-22 The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification Cheng, Tiffany W. Ahern, Madeline C. Giubellino, Alessio Front Oncol Oncology Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions. Frontiers Media S.A. 2022-06-07 /pmc/articles/PMC9209745/ /pubmed/35747831 http://dx.doi.org/10.3389/fonc.2022.889223 Text en Copyright © 2022 Cheng, Ahern and Giubellino https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cheng, Tiffany W.
Ahern, Madeline C.
Giubellino, Alessio
The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title_full The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title_fullStr The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title_full_unstemmed The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title_short The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
title_sort spectrum of spitz melanocytic lesions: from morphologic diagnosis to molecular classification
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209745/
https://www.ncbi.nlm.nih.gov/pubmed/35747831
http://dx.doi.org/10.3389/fonc.2022.889223
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