Cargando…
The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification
Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examinat...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209745/ https://www.ncbi.nlm.nih.gov/pubmed/35747831 http://dx.doi.org/10.3389/fonc.2022.889223 |
_version_ | 1784730014464344064 |
---|---|
author | Cheng, Tiffany W. Ahern, Madeline C. Giubellino, Alessio |
author_facet | Cheng, Tiffany W. Ahern, Madeline C. Giubellino, Alessio |
author_sort | Cheng, Tiffany W. |
collection | PubMed |
description | Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions. |
format | Online Article Text |
id | pubmed-9209745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92097452022-06-22 The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification Cheng, Tiffany W. Ahern, Madeline C. Giubellino, Alessio Front Oncol Oncology Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions. Frontiers Media S.A. 2022-06-07 /pmc/articles/PMC9209745/ /pubmed/35747831 http://dx.doi.org/10.3389/fonc.2022.889223 Text en Copyright © 2022 Cheng, Ahern and Giubellino https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Cheng, Tiffany W. Ahern, Madeline C. Giubellino, Alessio The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title | The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title_full | The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title_fullStr | The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title_full_unstemmed | The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title_short | The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification |
title_sort | spectrum of spitz melanocytic lesions: from morphologic diagnosis to molecular classification |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209745/ https://www.ncbi.nlm.nih.gov/pubmed/35747831 http://dx.doi.org/10.3389/fonc.2022.889223 |
work_keys_str_mv | AT chengtiffanyw thespectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification AT ahernmadelinec thespectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification AT giubellinoalessio thespectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification AT chengtiffanyw spectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification AT ahernmadelinec spectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification AT giubellinoalessio spectrumofspitzmelanocyticlesionsfrommorphologicdiagnosistomolecularclassification |