Wee1 kinase inhibitor adavosertib with radiation in newly diagnosed diffuse intrinsic pontine glioma: A Children’s Oncology Group phase I consortium study

BACKGROUND: Children with diffuse intrinsic pontine gliomas (DIPG) have a dismal prognosis. Adavosertib (AZD1775) is an orally available, blood-brain barrier penetrant, Wee1 kinase inhibitor. Preclinical efficacy against DIPG is heightened by radiation induced replication stress. METHODS: Using a ro...

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Detalles Bibliográficos
Autores principales: Mueller, Sabine, Cooney, Tabitha, Yang, Xiaodong, Pal, Sharmistha, Ermoian, Ralph, Gajjar, Amar, Liu, Xiaowei, Prem, Komal, Minard, Charles G, Reid, Joel M, Nelson, Marvin, Haas-Kogan, Daphne, Fox, Elizabeth, Weigel, Brenda J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209747/
https://www.ncbi.nlm.nih.gov/pubmed/35733515
http://dx.doi.org/10.1093/noajnl/vdac073

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