Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

BACKGROUND & AIMS: Acetaminophen (APAP) overdose remains a frequent cause of acute liver failure, which is generally accompanied by increased levels of serum bile acids (BAs). However, the pathophysiological role of BAs remains elusive. Herein, we investigated the role of BAs in APAP-induced hep...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghallab, Ahmed, Hassan, Reham, Hofmann, Ute, Friebel, Adrian, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Myllys, Maiju, Reinders, Joerg, Overbeck, Nina, Sezgin, Selahaddin, Zühlke, Sebastian, Seddek, Abdel-latif, Murad, Walaa, Brecklinghaus, Tim, Kappenberg, Franziska, Rahnenführer, Jörg, González, Daniela, Goldring, Christopher, Copple, Ian M., Marchan, Rosemarie, Longerich, Thomas, Vucur, Mihael, Luedde, Tom, Urban, Stephan, Canbay, Ali, Schreiter, Thomas, Trauner, Michael, Akakpo, Jephte Y., Olyaee, Mojtaba, Curry, Steven C., Sowa, Jan-Peter, Jaeschke, Hartmut, Hoehme, Stefan, Hengstler, Jan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209783/
https://www.ncbi.nlm.nih.gov/pubmed/35131407
http://dx.doi.org/10.1016/j.jhep.2022.01.020

Ejemplares similares

Ejemplares similares