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Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial
OBJECTIVE: To evaluate the clinical efficacy of intralesional platelet‐rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP). MATERIAL AND METHODS: Twenty patients with EOLP were assigned randomly to eithe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209796/ https://www.ncbi.nlm.nih.gov/pubmed/35218680 http://dx.doi.org/10.1002/cre2.550 |
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author | Hijazi, AbdelHameed Ahmed, Wesam Gaafar, Soheir |
author_facet | Hijazi, AbdelHameed Ahmed, Wesam Gaafar, Soheir |
author_sort | Hijazi, AbdelHameed |
collection | PubMed |
description | OBJECTIVE: To evaluate the clinical efficacy of intralesional platelet‐rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP). MATERIAL AND METHODS: Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded. RESULTS: Both groups showed significant improvement in the clinical parameters (pain and clinical score) “p = .001.” Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission. CONCLUSIONS: PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368. |
format | Online Article Text |
id | pubmed-9209796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92097962022-06-28 Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial Hijazi, AbdelHameed Ahmed, Wesam Gaafar, Soheir Clin Exp Dent Res Original Articles OBJECTIVE: To evaluate the clinical efficacy of intralesional platelet‐rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP). MATERIAL AND METHODS: Twenty patients with EOLP were assigned randomly to either PRP or TA group. Patients received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain scores using numerical pain score and clinical score were recorded by a blinded assessor each visit for all patients and remission score at the end of the trial was recorded. RESULTS: Both groups showed significant improvement in the clinical parameters (pain and clinical score) “p = .001.” Regarding remission of the lesions, 80% of patients in the PRP group showed complete remission compared to 70% in the TA group. However, there is no statistical significance when comparing the two groups in pain score, clinical score, or remission. CONCLUSIONS: PRP injections could be considered as an effective alternative single treatment modality for EOLP. The protocol for this study registered in Clinicaltrials.gov registry under the identifier number: NCT03293368. John Wiley and Sons Inc. 2022-02-26 /pmc/articles/PMC9209796/ /pubmed/35218680 http://dx.doi.org/10.1002/cre2.550 Text en © 2022 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Hijazi, AbdelHameed Ahmed, Wesam Gaafar, Soheir Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title | Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title_full | Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title_fullStr | Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title_full_unstemmed | Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title_short | Efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: A pilot randomized clinical trial |
title_sort | efficacy of intralesional injections of platelet‐rich plasma in patients with oral lichen planus: a pilot randomized clinical trial |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209796/ https://www.ncbi.nlm.nih.gov/pubmed/35218680 http://dx.doi.org/10.1002/cre2.550 |
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