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Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial

BACKGROUND: Obstructive sleep apnoea (OSA) is a common chronic condition that is associated with significant morbidity and economic cost. Prolonged wait times are increasingly being recognised as a barrier to diagnosis and treatment of many chronic diseases; however, no study to date has prospective...

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Autores principales: Thornton, Christina S., Povitz, Marcus, Tsai, Willis H., Loewen, Andrea H., Ip-Buting, Ada, Kendzerska, Tetyana, Flemons, W. Ward, Fraser, Kristin L., Hanly, Patrick J., Pendharkar, Sachin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209848/
https://www.ncbi.nlm.nih.gov/pubmed/35747231
http://dx.doi.org/10.1183/23120541.00068-2022
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author Thornton, Christina S.
Povitz, Marcus
Tsai, Willis H.
Loewen, Andrea H.
Ip-Buting, Ada
Kendzerska, Tetyana
Flemons, W. Ward
Fraser, Kristin L.
Hanly, Patrick J.
Pendharkar, Sachin R.
author_facet Thornton, Christina S.
Povitz, Marcus
Tsai, Willis H.
Loewen, Andrea H.
Ip-Buting, Ada
Kendzerska, Tetyana
Flemons, W. Ward
Fraser, Kristin L.
Hanly, Patrick J.
Pendharkar, Sachin R.
author_sort Thornton, Christina S.
collection PubMed
description BACKGROUND: Obstructive sleep apnoea (OSA) is a common chronic condition that is associated with significant morbidity and economic cost. Prolonged wait times are increasingly being recognised as a barrier to diagnosis and treatment of many chronic diseases; however, no study to date has prospectively evaluated the impact of wait times on health outcomes in OSA. OBJECTIVE: The purpose of this study is to determine whether treatment outcomes for individuals with OSA differ between patients managed using an expedited versus standard pathway. METHODS: A pragmatic randomised controlled trial design will be used with a target sample size of 200 adults. Participants with clinically significant uncomplicated OSA will be recruited through referrals to a large tertiary care sleep centre (Calgary, AB, Canada) and randomised to either early management (within 1 month) or usual care (∼6 months) with a 1:1 allocation using a concealed computer-generated randomisation sequence. The primary outcome will be adherence to positive airway pressure (PAP) therapy at 3 months after treatment initiation. Secondary outcomes will include change in sleepiness, quality of life, patient satisfaction, and patient engagement with therapy from baseline to 3 months after PAP initiation, measured using validated questionnaires and qualitative methods. ANTICIPATED RESULTS: This study will determine whether expedited care for OSA leads to differences in PAP adherence and/or patient-reported outcomes. More broadly, the findings of this study may improve the understanding of how wait time reductions impact health outcomes for other chronic diseases.
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spelling pubmed-92098482022-06-22 Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial Thornton, Christina S. Povitz, Marcus Tsai, Willis H. Loewen, Andrea H. Ip-Buting, Ada Kendzerska, Tetyana Flemons, W. Ward Fraser, Kristin L. Hanly, Patrick J. Pendharkar, Sachin R. ERJ Open Res Study Protocols BACKGROUND: Obstructive sleep apnoea (OSA) is a common chronic condition that is associated with significant morbidity and economic cost. Prolonged wait times are increasingly being recognised as a barrier to diagnosis and treatment of many chronic diseases; however, no study to date has prospectively evaluated the impact of wait times on health outcomes in OSA. OBJECTIVE: The purpose of this study is to determine whether treatment outcomes for individuals with OSA differ between patients managed using an expedited versus standard pathway. METHODS: A pragmatic randomised controlled trial design will be used with a target sample size of 200 adults. Participants with clinically significant uncomplicated OSA will be recruited through referrals to a large tertiary care sleep centre (Calgary, AB, Canada) and randomised to either early management (within 1 month) or usual care (∼6 months) with a 1:1 allocation using a concealed computer-generated randomisation sequence. The primary outcome will be adherence to positive airway pressure (PAP) therapy at 3 months after treatment initiation. Secondary outcomes will include change in sleepiness, quality of life, patient satisfaction, and patient engagement with therapy from baseline to 3 months after PAP initiation, measured using validated questionnaires and qualitative methods. ANTICIPATED RESULTS: This study will determine whether expedited care for OSA leads to differences in PAP adherence and/or patient-reported outcomes. More broadly, the findings of this study may improve the understanding of how wait time reductions impact health outcomes for other chronic diseases. European Respiratory Society 2022-06-20 /pmc/articles/PMC9209848/ /pubmed/35747231 http://dx.doi.org/10.1183/23120541.00068-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Study Protocols
Thornton, Christina S.
Povitz, Marcus
Tsai, Willis H.
Loewen, Andrea H.
Ip-Buting, Ada
Kendzerska, Tetyana
Flemons, W. Ward
Fraser, Kristin L.
Hanly, Patrick J.
Pendharkar, Sachin R.
Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title_full Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title_fullStr Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title_full_unstemmed Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title_short Impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
title_sort impact of wait times for treatment on clinical outcomes in patients with obstructive sleep apnoea: protocol for a randomised controlled trial
topic Study Protocols
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209848/
https://www.ncbi.nlm.nih.gov/pubmed/35747231
http://dx.doi.org/10.1183/23120541.00068-2022
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