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A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia
A 36-year-old nullipara at 35 weeks of gestation woke up with slurred speech and dysphagia. The next day, she developed abruption of the placenta, underwent an acute cesarean, and was diagnosed with severe preeclampsia. Neurologic examination revealed flaccid dysarthria, bilateral soft palate palsy,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209946/ https://www.ncbi.nlm.nih.gov/pubmed/35815102 http://dx.doi.org/10.1159/000524459 |
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author | Zarifkar, Pardis Hansen, Klaus Crone, Clarissa Svenstrup, Kirsten Larsen, Vibeke Andrée Karlsson, William Kristian |
author_facet | Zarifkar, Pardis Hansen, Klaus Crone, Clarissa Svenstrup, Kirsten Larsen, Vibeke Andrée Karlsson, William Kristian |
author_sort | Zarifkar, Pardis |
collection | PubMed |
description | A 36-year-old nullipara at 35 weeks of gestation woke up with slurred speech and dysphagia. The next day, she developed abruption of the placenta, underwent an acute cesarean, and was diagnosed with severe preeclampsia. Neurologic examination revealed flaccid dysarthria, bilateral soft palate palsy, reduced taste of the left posterior tongue, left-sided tongue deviation, and paralysis of the left sternocleidomastoid and trapezius muscles. MRI revealed left-sided tongue edema compatible with acute left hypoglossal nerve denervation and electromyography of the left trapezius and glossal muscles showed profuse denervation potentials. In conclusion, multiple cranial neuropathies may occur in and even be a presenting symptom of preeclampsia. In this study, we report the first case of multiple cranial neuropathies involving cranial nerves IX, X, XI, and XII in a patient with preeclampsia. Possible pathogenic mechanisms of cranial neuropathy in preeclampsia include immune-mediated neuropathy with or without demyelination, microvascular thromboses, and perineural edema. |
format | Online Article Text |
id | pubmed-9209946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-92099462022-07-08 A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia Zarifkar, Pardis Hansen, Klaus Crone, Clarissa Svenstrup, Kirsten Larsen, Vibeke Andrée Karlsson, William Kristian Case Rep Neurol Single Case − General Neurology A 36-year-old nullipara at 35 weeks of gestation woke up with slurred speech and dysphagia. The next day, she developed abruption of the placenta, underwent an acute cesarean, and was diagnosed with severe preeclampsia. Neurologic examination revealed flaccid dysarthria, bilateral soft palate palsy, reduced taste of the left posterior tongue, left-sided tongue deviation, and paralysis of the left sternocleidomastoid and trapezius muscles. MRI revealed left-sided tongue edema compatible with acute left hypoglossal nerve denervation and electromyography of the left trapezius and glossal muscles showed profuse denervation potentials. In conclusion, multiple cranial neuropathies may occur in and even be a presenting symptom of preeclampsia. In this study, we report the first case of multiple cranial neuropathies involving cranial nerves IX, X, XI, and XII in a patient with preeclampsia. Possible pathogenic mechanisms of cranial neuropathy in preeclampsia include immune-mediated neuropathy with or without demyelination, microvascular thromboses, and perineural edema. S. Karger AG 2022-05-30 /pmc/articles/PMC9209946/ /pubmed/35815102 http://dx.doi.org/10.1159/000524459 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Single Case − General Neurology Zarifkar, Pardis Hansen, Klaus Crone, Clarissa Svenstrup, Kirsten Larsen, Vibeke Andrée Karlsson, William Kristian A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title | A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title_full | A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title_fullStr | A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title_full_unstemmed | A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title_short | A Unique Constellation of Multiple Cranial Neuropathies in a Patient with Preeclampsia |
title_sort | unique constellation of multiple cranial neuropathies in a patient with preeclampsia |
topic | Single Case − General Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9209946/ https://www.ncbi.nlm.nih.gov/pubmed/35815102 http://dx.doi.org/10.1159/000524459 |
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