Cargando…

Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis

BACKGROUND: Malignant bowel obstruction is a common cause of morbidity and mortality in patients with advanced ovarian cancer. Many patients aren’t suitable for, or decline, surgical decompression. The outcomes for this frail group of patients are not well characterized. AIM: To evaluate survival ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Idaikkadar, Praveena, Georgiou, Athina, Skene, Simon, Michael, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210105/
https://www.ncbi.nlm.nih.gov/pubmed/34490792
http://dx.doi.org/10.1177/10499091211043079
_version_ 1784730089322184704
author Idaikkadar, Praveena
Georgiou, Athina
Skene, Simon
Michael, Agnieszka
author_facet Idaikkadar, Praveena
Georgiou, Athina
Skene, Simon
Michael, Agnieszka
author_sort Idaikkadar, Praveena
collection PubMed
description BACKGROUND: Malignant bowel obstruction is a common cause of morbidity and mortality in patients with advanced ovarian cancer. Many patients aren’t suitable for, or decline, surgical decompression. The outcomes for this frail group of patients are not well characterized. AIM: To evaluate survival outcomes of ovarian cancer patients who undergo non-surgical management of malignant bowel obstruction. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Online literature search of Pubmed, Embase and Medline libraries up until December 2020. Searching abstracts of scientific meetings, reference lists of included studies and contacting experts in the field. SELECTION CRITERIA: Studies that investigated non-surgical management of confirmed bowel obstruction in advanced ovarian cancer patients were included. All levels of evidence including RCTs, cohort studies and case-series if they included greater than 5 patients. DATA COLLECTION AND ANALYSIS: The studies were independently chosen by two reviewers who extracted and analyzed the data separately through OpenMeta Analyst software. Study quality was assessed using the JADAD score and the Newcastle Ottawa Score. RESULTS: 24 studies met the eligibility criteria for the systematic review and 9 for the meta-analysis. Median survival of patients managed non-surgically for bowel obstruction was 44 days (95% CI 38-49 days, I (2) = 0%, P = 0.128). CONCLUSION: The quality of studies was relatively low, however the evidence shows that non-surgical management of bowel obstruction results in a short life expectancy but with controlled symptoms. Where quality of life is the main concern, this may be a feasible and effective strategy.
format Online
Article
Text
id pubmed-9210105
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-92101052022-06-22 Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis Idaikkadar, Praveena Georgiou, Athina Skene, Simon Michael, Agnieszka Am J Hosp Palliat Care Review Articles BACKGROUND: Malignant bowel obstruction is a common cause of morbidity and mortality in patients with advanced ovarian cancer. Many patients aren’t suitable for, or decline, surgical decompression. The outcomes for this frail group of patients are not well characterized. AIM: To evaluate survival outcomes of ovarian cancer patients who undergo non-surgical management of malignant bowel obstruction. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Online literature search of Pubmed, Embase and Medline libraries up until December 2020. Searching abstracts of scientific meetings, reference lists of included studies and contacting experts in the field. SELECTION CRITERIA: Studies that investigated non-surgical management of confirmed bowel obstruction in advanced ovarian cancer patients were included. All levels of evidence including RCTs, cohort studies and case-series if they included greater than 5 patients. DATA COLLECTION AND ANALYSIS: The studies were independently chosen by two reviewers who extracted and analyzed the data separately through OpenMeta Analyst software. Study quality was assessed using the JADAD score and the Newcastle Ottawa Score. RESULTS: 24 studies met the eligibility criteria for the systematic review and 9 for the meta-analysis. Median survival of patients managed non-surgically for bowel obstruction was 44 days (95% CI 38-49 days, I (2) = 0%, P = 0.128). CONCLUSION: The quality of studies was relatively low, however the evidence shows that non-surgical management of bowel obstruction results in a short life expectancy but with controlled symptoms. Where quality of life is the main concern, this may be a feasible and effective strategy. SAGE Publications 2021-09-07 2022-07 /pmc/articles/PMC9210105/ /pubmed/34490792 http://dx.doi.org/10.1177/10499091211043079 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Articles
Idaikkadar, Praveena
Georgiou, Athina
Skene, Simon
Michael, Agnieszka
Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title_full Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title_fullStr Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title_short Non-Surgical Management of Malignant Bowel Obstruction in Advanced Ovarian Cancer patients: A Systematic Review and Meta-Analysis
title_sort non-surgical management of malignant bowel obstruction in advanced ovarian cancer patients: a systematic review and meta-analysis
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210105/
https://www.ncbi.nlm.nih.gov/pubmed/34490792
http://dx.doi.org/10.1177/10499091211043079
work_keys_str_mv AT idaikkadarpraveena nonsurgicalmanagementofmalignantbowelobstructioninadvancedovariancancerpatientsasystematicreviewandmetaanalysis
AT georgiouathina nonsurgicalmanagementofmalignantbowelobstructioninadvancedovariancancerpatientsasystematicreviewandmetaanalysis
AT skenesimon nonsurgicalmanagementofmalignantbowelobstructioninadvancedovariancancerpatientsasystematicreviewandmetaanalysis
AT michaelagnieszka nonsurgicalmanagementofmalignantbowelobstructioninadvancedovariancancerpatientsasystematicreviewandmetaanalysis