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Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210451/ https://www.ncbi.nlm.nih.gov/pubmed/35699621 http://dx.doi.org/10.1126/science.abq1841 |
| _version_ | 1784730160394665984 |
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| author | Reynolds, Catherine J. Pade, Corinna Gibbons, Joseph M. Otter, Ashley D. Lin, Kai-Min Muñoz Sandoval, Diana Pieper, Franziska P. Butler, David K. Liu, Siyi Joy, George Forooghi, Nasim Treibel, Thomas A. Manisty, Charlotte Moon, James C. Semper, Amanda Brooks, Tim McKnight, Áine Altmann, Daniel M. Boyton, Rosemary J. Abbass, Hakam Abiodun, Aderonke Alfarih, Mashael Alldis, Zoe Altmann, Daniel M. Amin, Oliver E. Andiapen, Mervyn Artico, Jessica Augusto, João B. Baca, Georgina L. Bailey, Sasha N. L. Bhuva, Anish N. Boulter, Alex Bowles, Ruth Boyton, Rosemary J. Bracken, Olivia V. O’Brien, Ben Brooks, Tim Bullock, Natalie Butler, David K. Captur, Gabriella Carr, Olivia Champion, Nicola Chan, Carmen Chandran, Aneesh Coleman, Tom Couto de Sousa, Jorge Couto-Parada, Xose Cross, Eleanor Cutino-Moguel, Teresa D’Arcangelo, Silvia Davies, Rhodri H. Douglas, Brooke Di Genova, Cecilia Dieobi-Anene, Keenan Diniz, Mariana O. Ellis, Anaya Feehan, Karen Finlay, Malcolm Fontana, Marianna Forooghi, Nasim Francis, Sasha Gibbons, Joseph M. Gillespie, David Gilroy, Derek Hamblin, Matt Harker, Gabrielle Hemingway, Georgia Hewson, Jacqueline Heywood, Wendy Hickling, Lauren M. Hicks, Bethany Hingorani, Aroon D. Howes, Lee Itua, Ivie Jardim, Victor Lee, Wing-Yiu Jason Jensen, Melaniepetra Jones, Jessica Jones, Meleri Joy, George Kapil, Vikas Kelly, Caoimhe Kurdi, Hibba Lambourne, Jonathan Lin, Kai-Min Liu, Siyi Lloyd, Aaron Louth, Sarah Maini, Mala K. Mandadapu, Vineela Manisty, Charlotte McKnight, Áine Menacho, Katia Mfuko, Celina Mills, Kevin Millward, Sebastian Mitchelmore, Oliver Moon, Christopher Moon, James Muñoz Sandoval, Diana Murray, Sam M. Noursadeghi, Mahdad Otter, Ashley Pade, Corinna Palma, Susana Parker, Ruth Patel, Kush Pawarova, Mihaela Petersen, Steffen E. Piniera, Brian Pieper, Franziska P. Rannigan, Lisa Rapala, Alicja Reynolds, Catherine J. Richards, Amy Robathan, Matthew Rosenheim, Joshua Rowe, Cathy Royds, Matthew Sackville West, Jane Sambile, Genine Schmidt, Nathalie M. Selman, Hannah Semper, Amanda Seraphim, Andreas Simion, Mihaela Smit, Angelique Sugimoto, Michelle Swadling, Leo Taylor, Stephen Temperton, Nigel Thomas, Stephen Thornton, George D. Treibel, Thomas A. Tucker, Art Varghese, Ann Veerapen, Jessry Vijayakumar, Mohit Warner, Tim Welch, Sophie White, Hannah Wodehouse, Theresa Wynne, Lucinda Zahedi, Dan Chain, Benjamin Moon, James C. |
| author_facet | Reynolds, Catherine J. Pade, Corinna Gibbons, Joseph M. Otter, Ashley D. Lin, Kai-Min Muñoz Sandoval, Diana Pieper, Franziska P. Butler, David K. Liu, Siyi Joy, George Forooghi, Nasim Treibel, Thomas A. Manisty, Charlotte Moon, James C. Semper, Amanda Brooks, Tim McKnight, Áine Altmann, Daniel M. Boyton, Rosemary J. Abbass, Hakam Abiodun, Aderonke Alfarih, Mashael Alldis, Zoe Altmann, Daniel M. Amin, Oliver E. Andiapen, Mervyn Artico, Jessica Augusto, João B. Baca, Georgina L. Bailey, Sasha N. L. Bhuva, Anish N. Boulter, Alex Bowles, Ruth Boyton, Rosemary J. Bracken, Olivia V. O’Brien, Ben Brooks, Tim Bullock, Natalie Butler, David K. Captur, Gabriella Carr, Olivia Champion, Nicola Chan, Carmen Chandran, Aneesh Coleman, Tom Couto de Sousa, Jorge Couto-Parada, Xose Cross, Eleanor Cutino-Moguel, Teresa D’Arcangelo, Silvia Davies, Rhodri H. Douglas, Brooke Di Genova, Cecilia Dieobi-Anene, Keenan Diniz, Mariana O. Ellis, Anaya Feehan, Karen Finlay, Malcolm Fontana, Marianna Forooghi, Nasim Francis, Sasha Gibbons, Joseph M. Gillespie, David Gilroy, Derek Hamblin, Matt Harker, Gabrielle Hemingway, Georgia Hewson, Jacqueline Heywood, Wendy Hickling, Lauren M. Hicks, Bethany Hingorani, Aroon D. Howes, Lee Itua, Ivie Jardim, Victor Lee, Wing-Yiu Jason Jensen, Melaniepetra Jones, Jessica Jones, Meleri Joy, George Kapil, Vikas Kelly, Caoimhe Kurdi, Hibba Lambourne, Jonathan Lin, Kai-Min Liu, Siyi Lloyd, Aaron Louth, Sarah Maini, Mala K. Mandadapu, Vineela Manisty, Charlotte McKnight, Áine Menacho, Katia Mfuko, Celina Mills, Kevin Millward, Sebastian Mitchelmore, Oliver Moon, Christopher Moon, James Muñoz Sandoval, Diana Murray, Sam M. Noursadeghi, Mahdad Otter, Ashley Pade, Corinna Palma, Susana Parker, Ruth Patel, Kush Pawarova, Mihaela Petersen, Steffen E. Piniera, Brian Pieper, Franziska P. Rannigan, Lisa Rapala, Alicja Reynolds, Catherine J. Richards, Amy Robathan, Matthew Rosenheim, Joshua Rowe, Cathy Royds, Matthew Sackville West, Jane Sambile, Genine Schmidt, Nathalie M. Selman, Hannah Semper, Amanda Seraphim, Andreas Simion, Mihaela Smit, Angelique Sugimoto, Michelle Swadling, Leo Taylor, Stephen Temperton, Nigel Thomas, Stephen Thornton, George D. Treibel, Thomas A. Tucker, Art Varghese, Ann Veerapen, Jessry Vijayakumar, Mohit Warner, Tim Welch, Sophie White, Hannah Wodehouse, Theresa Wynne, Lucinda Zahedi, Dan Chain, Benjamin Moon, James C. |
| author_sort | Reynolds, Catherine J. |
| collection | PubMed |
| description | The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529. |
| format | Online Article Text |
| id | pubmed-9210451 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92104512022-06-29 Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure Reynolds, Catherine J. Pade, Corinna Gibbons, Joseph M. Otter, Ashley D. Lin, Kai-Min Muñoz Sandoval, Diana Pieper, Franziska P. Butler, David K. Liu, Siyi Joy, George Forooghi, Nasim Treibel, Thomas A. Manisty, Charlotte Moon, James C. Semper, Amanda Brooks, Tim McKnight, Áine Altmann, Daniel M. Boyton, Rosemary J. Abbass, Hakam Abiodun, Aderonke Alfarih, Mashael Alldis, Zoe Altmann, Daniel M. Amin, Oliver E. Andiapen, Mervyn Artico, Jessica Augusto, João B. Baca, Georgina L. Bailey, Sasha N. L. Bhuva, Anish N. Boulter, Alex Bowles, Ruth Boyton, Rosemary J. Bracken, Olivia V. O’Brien, Ben Brooks, Tim Bullock, Natalie Butler, David K. Captur, Gabriella Carr, Olivia Champion, Nicola Chan, Carmen Chandran, Aneesh Coleman, Tom Couto de Sousa, Jorge Couto-Parada, Xose Cross, Eleanor Cutino-Moguel, Teresa D’Arcangelo, Silvia Davies, Rhodri H. Douglas, Brooke Di Genova, Cecilia Dieobi-Anene, Keenan Diniz, Mariana O. Ellis, Anaya Feehan, Karen Finlay, Malcolm Fontana, Marianna Forooghi, Nasim Francis, Sasha Gibbons, Joseph M. Gillespie, David Gilroy, Derek Hamblin, Matt Harker, Gabrielle Hemingway, Georgia Hewson, Jacqueline Heywood, Wendy Hickling, Lauren M. Hicks, Bethany Hingorani, Aroon D. Howes, Lee Itua, Ivie Jardim, Victor Lee, Wing-Yiu Jason Jensen, Melaniepetra Jones, Jessica Jones, Meleri Joy, George Kapil, Vikas Kelly, Caoimhe Kurdi, Hibba Lambourne, Jonathan Lin, Kai-Min Liu, Siyi Lloyd, Aaron Louth, Sarah Maini, Mala K. Mandadapu, Vineela Manisty, Charlotte McKnight, Áine Menacho, Katia Mfuko, Celina Mills, Kevin Millward, Sebastian Mitchelmore, Oliver Moon, Christopher Moon, James Muñoz Sandoval, Diana Murray, Sam M. Noursadeghi, Mahdad Otter, Ashley Pade, Corinna Palma, Susana Parker, Ruth Patel, Kush Pawarova, Mihaela Petersen, Steffen E. Piniera, Brian Pieper, Franziska P. Rannigan, Lisa Rapala, Alicja Reynolds, Catherine J. Richards, Amy Robathan, Matthew Rosenheim, Joshua Rowe, Cathy Royds, Matthew Sackville West, Jane Sambile, Genine Schmidt, Nathalie M. Selman, Hannah Semper, Amanda Seraphim, Andreas Simion, Mihaela Smit, Angelique Sugimoto, Michelle Swadling, Leo Taylor, Stephen Temperton, Nigel Thomas, Stephen Thornton, George D. Treibel, Thomas A. Tucker, Art Varghese, Ann Veerapen, Jessry Vijayakumar, Mohit Warner, Tim Welch, Sophie White, Hannah Wodehouse, Theresa Wynne, Lucinda Zahedi, Dan Chain, Benjamin Moon, James C. Science Research Articles The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529. American Association for the Advancement of Science 2022-06-14 /pmc/articles/PMC9210451/ /pubmed/35699621 http://dx.doi.org/10.1126/science.abq1841 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Articles Reynolds, Catherine J. Pade, Corinna Gibbons, Joseph M. Otter, Ashley D. Lin, Kai-Min Muñoz Sandoval, Diana Pieper, Franziska P. Butler, David K. Liu, Siyi Joy, George Forooghi, Nasim Treibel, Thomas A. Manisty, Charlotte Moon, James C. Semper, Amanda Brooks, Tim McKnight, Áine Altmann, Daniel M. Boyton, Rosemary J. Abbass, Hakam Abiodun, Aderonke Alfarih, Mashael Alldis, Zoe Altmann, Daniel M. Amin, Oliver E. Andiapen, Mervyn Artico, Jessica Augusto, João B. Baca, Georgina L. Bailey, Sasha N. L. Bhuva, Anish N. Boulter, Alex Bowles, Ruth Boyton, Rosemary J. Bracken, Olivia V. O’Brien, Ben Brooks, Tim Bullock, Natalie Butler, David K. Captur, Gabriella Carr, Olivia Champion, Nicola Chan, Carmen Chandran, Aneesh Coleman, Tom Couto de Sousa, Jorge Couto-Parada, Xose Cross, Eleanor Cutino-Moguel, Teresa D’Arcangelo, Silvia Davies, Rhodri H. Douglas, Brooke Di Genova, Cecilia Dieobi-Anene, Keenan Diniz, Mariana O. Ellis, Anaya Feehan, Karen Finlay, Malcolm Fontana, Marianna Forooghi, Nasim Francis, Sasha Gibbons, Joseph M. Gillespie, David Gilroy, Derek Hamblin, Matt Harker, Gabrielle Hemingway, Georgia Hewson, Jacqueline Heywood, Wendy Hickling, Lauren M. Hicks, Bethany Hingorani, Aroon D. Howes, Lee Itua, Ivie Jardim, Victor Lee, Wing-Yiu Jason Jensen, Melaniepetra Jones, Jessica Jones, Meleri Joy, George Kapil, Vikas Kelly, Caoimhe Kurdi, Hibba Lambourne, Jonathan Lin, Kai-Min Liu, Siyi Lloyd, Aaron Louth, Sarah Maini, Mala K. Mandadapu, Vineela Manisty, Charlotte McKnight, Áine Menacho, Katia Mfuko, Celina Mills, Kevin Millward, Sebastian Mitchelmore, Oliver Moon, Christopher Moon, James Muñoz Sandoval, Diana Murray, Sam M. Noursadeghi, Mahdad Otter, Ashley Pade, Corinna Palma, Susana Parker, Ruth Patel, Kush Pawarova, Mihaela Petersen, Steffen E. Piniera, Brian Pieper, Franziska P. Rannigan, Lisa Rapala, Alicja Reynolds, Catherine J. Richards, Amy Robathan, Matthew Rosenheim, Joshua Rowe, Cathy Royds, Matthew Sackville West, Jane Sambile, Genine Schmidt, Nathalie M. Selman, Hannah Semper, Amanda Seraphim, Andreas Simion, Mihaela Smit, Angelique Sugimoto, Michelle Swadling, Leo Taylor, Stephen Temperton, Nigel Thomas, Stephen Thornton, George D. Treibel, Thomas A. Tucker, Art Varghese, Ann Veerapen, Jessry Vijayakumar, Mohit Warner, Tim Welch, Sophie White, Hannah Wodehouse, Theresa Wynne, Lucinda Zahedi, Dan Chain, Benjamin Moon, James C. Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title_full | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title_fullStr | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title_full_unstemmed | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title_short | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
| title_sort | immune boosting by b.1.1.529 (omicron) depends on previous sars-cov-2 exposure |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210451/ https://www.ncbi.nlm.nih.gov/pubmed/35699621 http://dx.doi.org/10.1126/science.abq1841 |
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immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT thorntongeorged immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT treibelthomasa immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT tuckerart immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT vargheseann immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT veerapenjessry immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT vijayakumarmohit immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT warnertim immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT welchsophie immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT whitehannah immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT wodehousetheresa immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT wynnelucinda immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT zahedidan immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT chainbenjamin immuneboostingbyb11529omicrondependsonprevioussarscov2exposure AT moonjamesc immuneboostingbyb11529omicrondependsonprevioussarscov2exposure |