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Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study

BACKGROUND & OBJECTIVES: A high incidence of gallbladder cancer (GBC) is observed in northern India. This study was aimed to identify the factors involved in developing GBC in this region. METHODS: A gallstones-matched, case–control study was conducted in northern India. Ninety nine patients wit...

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Autores principales: Mishra, Kumudesh, Behari, Anu, Shukla, Pooja, Tsuchiya, Yasuo, Endoh, Kazuo, Asai, Takao, Ikoma, Toshikazu, Nakamura, Kazutoshi, Kapoor, Vinay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210525/
https://www.ncbi.nlm.nih.gov/pubmed/35532588
http://dx.doi.org/10.4103/ijmr.IJMR_201_19
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author Mishra, Kumudesh
Behari, Anu
Shukla, Pooja
Tsuchiya, Yasuo
Endoh, Kazuo
Asai, Takao
Ikoma, Toshikazu
Nakamura, Kazutoshi
Kapoor, Vinay Kumar
author_facet Mishra, Kumudesh
Behari, Anu
Shukla, Pooja
Tsuchiya, Yasuo
Endoh, Kazuo
Asai, Takao
Ikoma, Toshikazu
Nakamura, Kazutoshi
Kapoor, Vinay Kumar
author_sort Mishra, Kumudesh
collection PubMed
description BACKGROUND & OBJECTIVES: A high incidence of gallbladder cancer (GBC) is observed in northern India. This study was aimed to identify the factors involved in developing GBC in this region. METHODS: A gallstones-matched, case–control study was conducted in northern India. Ninety nine patients with GBC and gallstones (33 men and 66 women, mean age of 51.4 yr) comprised the case group, while 99 patients with cholelithiasis (40 men and 59 women, mean age of 45.7 yr) comprised the control group. All participants were interviewed to complete 183 questionnaire items that included 105 food items. Potential risk factors were identified using a multivariate analysis adjusted for age and sex. Significant risk factors were identified using a stepwise logistic-regression analysis. RESULTS: Age (≥50 yr), education (illiterate), socioeconomic status (≤below poverty line), bowel habits (≤once a day), hypertension history, hypotensive drug use, non-vegetarian diet, use of firewood for cooking, tap water drinking, hand pump water drinking and high consumption of coffee and sweets were identified as the potential risk factors. In women, factors included menarche (<13 yr), number of pregnancies (≥3 pregnancies) and parity (≥3 babies). Of these factors, age, education, bowel habits, tap water drinking and multiple pregnancy and/or multiparity were identified as significant risk factors, whereas a high consumption of coffee and sweets or hypotensive drug use and/or hypertension history were protective factors. INTERPRETATION & CONCLUSIONS: Poor bowel habits and drinking unsafe water appear to be the main risk factors for developing GBC. These are, however, modifiable factors which are capable of decreasing the risk of GBC in the north Indian population.
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spelling pubmed-92105252022-06-22 Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study Mishra, Kumudesh Behari, Anu Shukla, Pooja Tsuchiya, Yasuo Endoh, Kazuo Asai, Takao Ikoma, Toshikazu Nakamura, Kazutoshi Kapoor, Vinay Kumar Indian J Med Res Original Article BACKGROUND & OBJECTIVES: A high incidence of gallbladder cancer (GBC) is observed in northern India. This study was aimed to identify the factors involved in developing GBC in this region. METHODS: A gallstones-matched, case–control study was conducted in northern India. Ninety nine patients with GBC and gallstones (33 men and 66 women, mean age of 51.4 yr) comprised the case group, while 99 patients with cholelithiasis (40 men and 59 women, mean age of 45.7 yr) comprised the control group. All participants were interviewed to complete 183 questionnaire items that included 105 food items. Potential risk factors were identified using a multivariate analysis adjusted for age and sex. Significant risk factors were identified using a stepwise logistic-regression analysis. RESULTS: Age (≥50 yr), education (illiterate), socioeconomic status (≤below poverty line), bowel habits (≤once a day), hypertension history, hypotensive drug use, non-vegetarian diet, use of firewood for cooking, tap water drinking, hand pump water drinking and high consumption of coffee and sweets were identified as the potential risk factors. In women, factors included menarche (<13 yr), number of pregnancies (≥3 pregnancies) and parity (≥3 babies). Of these factors, age, education, bowel habits, tap water drinking and multiple pregnancy and/or multiparity were identified as significant risk factors, whereas a high consumption of coffee and sweets or hypotensive drug use and/or hypertension history were protective factors. INTERPRETATION & CONCLUSIONS: Poor bowel habits and drinking unsafe water appear to be the main risk factors for developing GBC. These are, however, modifiable factors which are capable of decreasing the risk of GBC in the north Indian population. Wolters Kluwer - Medknow 2021-11 /pmc/articles/PMC9210525/ /pubmed/35532588 http://dx.doi.org/10.4103/ijmr.IJMR_201_19 Text en Copyright: © 2022 Indian Journal of Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mishra, Kumudesh
Behari, Anu
Shukla, Pooja
Tsuchiya, Yasuo
Endoh, Kazuo
Asai, Takao
Ikoma, Toshikazu
Nakamura, Kazutoshi
Kapoor, Vinay Kumar
Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title_full Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title_fullStr Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title_full_unstemmed Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title_short Risk factors for gallbladder cancer development in northern India: A gallstones-matched, case–control study
title_sort risk factors for gallbladder cancer development in northern india: a gallstones-matched, case–control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210525/
https://www.ncbi.nlm.nih.gov/pubmed/35532588
http://dx.doi.org/10.4103/ijmr.IJMR_201_19
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