A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review

Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis factor-like we...

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Autores principales: Wang, Sijia, Li, Liang, Cook, Christopher, Zhang, Yufei, Xia, Yumin, Liu, Yale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210594/
https://www.ncbi.nlm.nih.gov/pubmed/35729659
http://dx.doi.org/10.1186/s13287-022-02930-z
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author Wang, Sijia
Li, Liang
Cook, Christopher
Zhang, Yufei
Xia, Yumin
Liu, Yale
author_facet Wang, Sijia
Li, Liang
Cook, Christopher
Zhang, Yufei
Xia, Yumin
Liu, Yale
author_sort Wang, Sijia
collection PubMed
description Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) acts on miscellaneous cells via binding to fibroblast growth factor-inducible 14 (Fn14) and exerts pleiotropic functions in the regulation of divergent stem cell fates. TWEAK/Fn14 signaling can regulate the proliferation, differentiation, and migration of multiple SPCs as well as tumorigenesis in certain contexts. Although TWEAK’s roles in modulating multiple SPCs are sparsely reported, the systemic effector functions of this multifaceted protein have not been fully elucidated. In this review, we summarized the fate decisions of TWEAK/Fn14 signaling on multiple stem cells and characterized its potential in stem cell therapy.
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spelling pubmed-92105942022-06-22 A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review Wang, Sijia Li, Liang Cook, Christopher Zhang, Yufei Xia, Yumin Liu, Yale Stem Cell Res Ther Review Stem and progenitor cells (SPCs) possess self-remodeling ability and differentiation potential and are responsible for the regeneration and development of organs and tissue systems. However, the precise mechanisms underlying the regulation of SPC biology remain unclear. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) acts on miscellaneous cells via binding to fibroblast growth factor-inducible 14 (Fn14) and exerts pleiotropic functions in the regulation of divergent stem cell fates. TWEAK/Fn14 signaling can regulate the proliferation, differentiation, and migration of multiple SPCs as well as tumorigenesis in certain contexts. Although TWEAK’s roles in modulating multiple SPCs are sparsely reported, the systemic effector functions of this multifaceted protein have not been fully elucidated. In this review, we summarized the fate decisions of TWEAK/Fn14 signaling on multiple stem cells and characterized its potential in stem cell therapy. BioMed Central 2022-06-21 /pmc/articles/PMC9210594/ /pubmed/35729659 http://dx.doi.org/10.1186/s13287-022-02930-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Sijia
Li, Liang
Cook, Christopher
Zhang, Yufei
Xia, Yumin
Liu, Yale
A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title_full A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title_fullStr A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title_full_unstemmed A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title_short A potential fate decision landscape of the TWEAK/Fn14 axis on stem and progenitor cells: a systematic review
title_sort potential fate decision landscape of the tweak/fn14 axis on stem and progenitor cells: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210594/
https://www.ncbi.nlm.nih.gov/pubmed/35729659
http://dx.doi.org/10.1186/s13287-022-02930-z
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