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Advances of exosomes in periodontitis treatment

Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells,...

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Autores principales: Lin, Hongbing, Chen, Huishan, Zhao, Xuetao, Ding, Tong, Wang, Yawei, Chen, Zhen, Tian, Yue, Zhang, Peipei, Shen, Yuqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210629/
https://www.ncbi.nlm.nih.gov/pubmed/35729576
http://dx.doi.org/10.1186/s12967-022-03487-4
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author Lin, Hongbing
Chen, Huishan
Zhao, Xuetao
Ding, Tong
Wang, Yawei
Chen, Zhen
Tian, Yue
Zhang, Peipei
Shen, Yuqin
author_facet Lin, Hongbing
Chen, Huishan
Zhao, Xuetao
Ding, Tong
Wang, Yawei
Chen, Zhen
Tian, Yue
Zhang, Peipei
Shen, Yuqin
author_sort Lin, Hongbing
collection PubMed
description Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5 years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics.
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spelling pubmed-92106292022-06-22 Advances of exosomes in periodontitis treatment Lin, Hongbing Chen, Huishan Zhao, Xuetao Ding, Tong Wang, Yawei Chen, Zhen Tian, Yue Zhang, Peipei Shen, Yuqin J Transl Med Review Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutrophils play pro-inflammatory or anti-inflammatory roles. Traditional therapies for periodontitis are effective in reducing the microbial quantities and improving the clinical symptoms of periodontitis. However, these methods are non-selective, and it is still challenging to achieve an ideal treatment effect in clinics using the currently available treatments and approaches. Exosomes have shown promising potential in various preclinical and clinical studies, including in the diagnosis and treatment of periodontitis. Exos can be secreted by almost all types of cells, containing specific substances of cells: RNA, free fatty acids, proteins, surface receptors and cytokines. Exos act as local and systemic intercellular communication medium, play significant roles in various biological functions, and regulate physiological and pathological processes in numerous diseases. Exos-based periodontitis diagnosis and treatment strategies have been reported to obtain the potential to overcome the drawbacks of traditional therapies. This review focuses on the accumulating evidence from the last 5 years, indicating the therapeutic potential of the Exos in preclinical and clinical studies of periodontitis. Recent advances on Exos-based periodontitis diagnosis and treatment strategies, existing challenges, and prospect are summarized as guidance to improve the effectiveness of Exos on periodontitis in clinics. BioMed Central 2022-06-21 /pmc/articles/PMC9210629/ /pubmed/35729576 http://dx.doi.org/10.1186/s12967-022-03487-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lin, Hongbing
Chen, Huishan
Zhao, Xuetao
Ding, Tong
Wang, Yawei
Chen, Zhen
Tian, Yue
Zhang, Peipei
Shen, Yuqin
Advances of exosomes in periodontitis treatment
title Advances of exosomes in periodontitis treatment
title_full Advances of exosomes in periodontitis treatment
title_fullStr Advances of exosomes in periodontitis treatment
title_full_unstemmed Advances of exosomes in periodontitis treatment
title_short Advances of exosomes in periodontitis treatment
title_sort advances of exosomes in periodontitis treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210629/
https://www.ncbi.nlm.nih.gov/pubmed/35729576
http://dx.doi.org/10.1186/s12967-022-03487-4
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