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Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star

Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally, robust biomarkers and satisfactory therapeut...

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Autores principales: Chen, Qun, Li, Jiajia, Shen, Peng, Yuan, Hao, Yin, Jie, Ge, Wanli, Wang, Wujun, Chen, Guangbin, Yang, Taoyue, Xiao, Bin, Miao, Yi, Lu, Zipeng, Wu, Pengfei, Jiang, Kuirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210669/
https://www.ncbi.nlm.nih.gov/pubmed/35729650
http://dx.doi.org/10.1186/s13578-022-00833-3
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author Chen, Qun
Li, Jiajia
Shen, Peng
Yuan, Hao
Yin, Jie
Ge, Wanli
Wang, Wujun
Chen, Guangbin
Yang, Taoyue
Xiao, Bin
Miao, Yi
Lu, Zipeng
Wu, Pengfei
Jiang, Kuirong
author_facet Chen, Qun
Li, Jiajia
Shen, Peng
Yuan, Hao
Yin, Jie
Ge, Wanli
Wang, Wujun
Chen, Guangbin
Yang, Taoyue
Xiao, Bin
Miao, Yi
Lu, Zipeng
Wu, Pengfei
Jiang, Kuirong
author_sort Chen, Qun
collection PubMed
description Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally, robust biomarkers and satisfactory therapeutic strategies for clinical use in PC patients are still lacking. Circular RNAs (circRNAs) are a new type of non-coding RNA originating from precursor messenger RNAs, with a covalent continuous closed-loop structure, strong stability and high specificity. Accumulating evidence suggests that circRNAs may participate in PC development and progression. Abnormal expression of circRNAs in PC is considered a vital factor that affects tumor cell proliferation, migration, invasion, apoptosis, angiogenesis and drug resistance. In this review of relevant articles published in recent years, we describe the basic knowledge concerning circRNAs, including their classification, biogenesis, functions and research approaches. Moreover, the biological roles and clinical significance of circRNAs related to PC are discussed. Finally, we note the questions remaining from recent studies and anticipate that further investigations will address these gaps in knowledge in this field. In conclusion, we expect to provide insights into circRNAs as potential targets for specific PC diagnosis and treatment in the future.
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spelling pubmed-92106692022-06-22 Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star Chen, Qun Li, Jiajia Shen, Peng Yuan, Hao Yin, Jie Ge, Wanli Wang, Wujun Chen, Guangbin Yang, Taoyue Xiao, Bin Miao, Yi Lu, Zipeng Wu, Pengfei Jiang, Kuirong Cell Biosci Review Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally, robust biomarkers and satisfactory therapeutic strategies for clinical use in PC patients are still lacking. Circular RNAs (circRNAs) are a new type of non-coding RNA originating from precursor messenger RNAs, with a covalent continuous closed-loop structure, strong stability and high specificity. Accumulating evidence suggests that circRNAs may participate in PC development and progression. Abnormal expression of circRNAs in PC is considered a vital factor that affects tumor cell proliferation, migration, invasion, apoptosis, angiogenesis and drug resistance. In this review of relevant articles published in recent years, we describe the basic knowledge concerning circRNAs, including their classification, biogenesis, functions and research approaches. Moreover, the biological roles and clinical significance of circRNAs related to PC are discussed. Finally, we note the questions remaining from recent studies and anticipate that further investigations will address these gaps in knowledge in this field. In conclusion, we expect to provide insights into circRNAs as potential targets for specific PC diagnosis and treatment in the future. BioMed Central 2022-06-21 /pmc/articles/PMC9210669/ /pubmed/35729650 http://dx.doi.org/10.1186/s13578-022-00833-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Qun
Li, Jiajia
Shen, Peng
Yuan, Hao
Yin, Jie
Ge, Wanli
Wang, Wujun
Chen, Guangbin
Yang, Taoyue
Xiao, Bin
Miao, Yi
Lu, Zipeng
Wu, Pengfei
Jiang, Kuirong
Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title_full Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title_fullStr Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title_full_unstemmed Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title_short Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star
title_sort biological functions, mechanisms, and clinical significance of circular rna in pancreatic cancer: a promising rising star
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210669/
https://www.ncbi.nlm.nih.gov/pubmed/35729650
http://dx.doi.org/10.1186/s13578-022-00833-3
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