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Exploring complement-dependent cytotoxicity by rituximab isotypes in 2D and 3D-cultured B-cell lymphoma

BACKGROUND: The therapeutic IgG1 anti-CD20 antibody, rituximab (RTX), has greatly improved prognosis of many B-cell malignancies. Despite its success, resistance has been reported and detailed knowledge of RTX mechanisms are lacking. Complement-dependent cytotoxicity (CDC) is one important mode of a...

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Detalles Bibliográficos
Autores principales:	Lara, Sandra, Heilig, Juliane, Virtanen, Alexander, Kleinau, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210731/ https://www.ncbi.nlm.nih.gov/pubmed/35725455 http://dx.doi.org/10.1186/s12885-022-09772-1

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