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Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma

OBJECTIVE: It has been reported that papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) are largely associated with adverse outcomes. The present study aimed to assess the correlation between the number of metastatic lymph nodes (NMLNs) and clinical prognosis in patients wit...

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Autores principales: Zhan, Ling, Feng, Hong-fang, Yu, Xi-zi, Li, Ling-rui, Song, Jun-long, Tu, Yi, Yuan, Jing-ping, Chen, Chuang, Sun, Sheng-rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210823/
https://www.ncbi.nlm.nih.gov/pubmed/35725426
http://dx.doi.org/10.1186/s12893-022-01635-7
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author Zhan, Ling
Feng, Hong-fang
Yu, Xi-zi
Li, Ling-rui
Song, Jun-long
Tu, Yi
Yuan, Jing-ping
Chen, Chuang
Sun, Sheng-rong
author_facet Zhan, Ling
Feng, Hong-fang
Yu, Xi-zi
Li, Ling-rui
Song, Jun-long
Tu, Yi
Yuan, Jing-ping
Chen, Chuang
Sun, Sheng-rong
author_sort Zhan, Ling
collection PubMed
description OBJECTIVE: It has been reported that papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) are largely associated with adverse outcomes. The present study aimed to assess the correlation between the number of metastatic lymph nodes (NMLNs) and clinical prognosis in patients with PTC. METHODS: We retrospectively reviewed the medical records of patients with PTC who underwent initial thyroid cancer surgery in Renmin Hospital of Wuhan University between 2017 and 2019. A total of 694 patients with PTC and cervical lymph node dissection as well as a total checked number of lymph nodes ≥ 5 were involved in this study. The clinicopathological characteristics of patients were compared according to NMLNs, the number of central cervical lymph nodes (CLNs) and the number of lateral lymph nodes (LLNs). RESULTS: NMLNs > 5, CLNs > 5 and LLNs > 5 were 222 (32.0%), 159 (24.3%) and 70 (10.1%) seen in the analyzed samples, respectively. Young patients, patients with larger tumor diameter, bilaterality, multifocality and gross extrathyroidal extension (ETE) were more inclined to NMLNs > 5, CLNs > 5 and LLNs > 5 (P < 0.05). It was found that the recurrence-free survival among pN1 patients was significantly discrepant between different groups (NMLNs ≤ 5/5: P = 0.001; LLNs ≤ 5/5: P < 0.001). In multivariate logistic regression analysis, patients aged < 55 years (OR = 1.917), primary tumor size > 10 mm (OR = 2.131), bilaterality (OR = 1.889) and tumor gross ETE (OR = 2.759) were independent predictors for high prevalence of total NMLNs > 5 (P < 0.05). Specially, patients aged < 55 years (OR = 2.864), primary tumor size > 10 mm (OR = 2.006), and tumor gross ETE (OR = 2.520) were independent predictors for high prevalence of CLNs > 5 (P < 0.01); Bilaterality (OR = 2.119), CLNs > 5 (OR = 6.733) and tumor gross ETE (OR = 4.737) were independent predictors for high prevalence of LLNs > 5 (P < 0.05). CONCLUSIONS: In conclusion, it is evident that NMLNs is related to the invasive clinicopathological features and adverse outcome of patients with PTC which should be correctly evaluated to provide an appropriate guidance for reasonable treatment and careful follow-up.
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spelling pubmed-92108232022-06-22 Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma Zhan, Ling Feng, Hong-fang Yu, Xi-zi Li, Ling-rui Song, Jun-long Tu, Yi Yuan, Jing-ping Chen, Chuang Sun, Sheng-rong BMC Surg Research Article OBJECTIVE: It has been reported that papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) are largely associated with adverse outcomes. The present study aimed to assess the correlation between the number of metastatic lymph nodes (NMLNs) and clinical prognosis in patients with PTC. METHODS: We retrospectively reviewed the medical records of patients with PTC who underwent initial thyroid cancer surgery in Renmin Hospital of Wuhan University between 2017 and 2019. A total of 694 patients with PTC and cervical lymph node dissection as well as a total checked number of lymph nodes ≥ 5 were involved in this study. The clinicopathological characteristics of patients were compared according to NMLNs, the number of central cervical lymph nodes (CLNs) and the number of lateral lymph nodes (LLNs). RESULTS: NMLNs > 5, CLNs > 5 and LLNs > 5 were 222 (32.0%), 159 (24.3%) and 70 (10.1%) seen in the analyzed samples, respectively. Young patients, patients with larger tumor diameter, bilaterality, multifocality and gross extrathyroidal extension (ETE) were more inclined to NMLNs > 5, CLNs > 5 and LLNs > 5 (P < 0.05). It was found that the recurrence-free survival among pN1 patients was significantly discrepant between different groups (NMLNs ≤ 5/5: P = 0.001; LLNs ≤ 5/5: P < 0.001). In multivariate logistic regression analysis, patients aged < 55 years (OR = 1.917), primary tumor size > 10 mm (OR = 2.131), bilaterality (OR = 1.889) and tumor gross ETE (OR = 2.759) were independent predictors for high prevalence of total NMLNs > 5 (P < 0.05). Specially, patients aged < 55 years (OR = 2.864), primary tumor size > 10 mm (OR = 2.006), and tumor gross ETE (OR = 2.520) were independent predictors for high prevalence of CLNs > 5 (P < 0.01); Bilaterality (OR = 2.119), CLNs > 5 (OR = 6.733) and tumor gross ETE (OR = 4.737) were independent predictors for high prevalence of LLNs > 5 (P < 0.05). CONCLUSIONS: In conclusion, it is evident that NMLNs is related to the invasive clinicopathological features and adverse outcome of patients with PTC which should be correctly evaluated to provide an appropriate guidance for reasonable treatment and careful follow-up. BioMed Central 2022-06-20 /pmc/articles/PMC9210823/ /pubmed/35725426 http://dx.doi.org/10.1186/s12893-022-01635-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhan, Ling
Feng, Hong-fang
Yu, Xi-zi
Li, Ling-rui
Song, Jun-long
Tu, Yi
Yuan, Jing-ping
Chen, Chuang
Sun, Sheng-rong
Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title_full Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title_fullStr Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title_full_unstemmed Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title_short Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
title_sort clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210823/
https://www.ncbi.nlm.nih.gov/pubmed/35725426
http://dx.doi.org/10.1186/s12893-022-01635-7
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