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Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature

BACKGROUND: Gastric neuroendocrine carcinoma (GNEC) is a rare histological subtype of gastric cancer, which is categorized into small cell and large cell neuroendocrine carcinomas. It is characterized by strong invasiveness and poor prognosis. Mixed large and small cell neuroendocrine carcinoma (L/S...

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Autores principales: Li, Ze-Feng, Lu, Hai-Zhen, Chen, Ying-Tai, Bai, Xiao-Feng, Wang, Tong-Bo, Fei, He, Zhao, Dong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210888/
https://www.ncbi.nlm.nih.gov/pubmed/35812663
http://dx.doi.org/10.12998/wjcc.v10.i16.5502
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author Li, Ze-Feng
Lu, Hai-Zhen
Chen, Ying-Tai
Bai, Xiao-Feng
Wang, Tong-Bo
Fei, He
Zhao, Dong-Bing
author_facet Li, Ze-Feng
Lu, Hai-Zhen
Chen, Ying-Tai
Bai, Xiao-Feng
Wang, Tong-Bo
Fei, He
Zhao, Dong-Bing
author_sort Li, Ze-Feng
collection PubMed
description BACKGROUND: Gastric neuroendocrine carcinoma (GNEC) is a rare histological subtype of gastric cancer, which is categorized into small cell and large cell neuroendocrine carcinomas. It is characterized by strong invasiveness and poor prognosis. Mixed large and small cell neuroendocrine carcinoma (L/SCNEC) is an extremely rare pathological type of gastric cancer, and there have been no reports on this situation until now. CASE SUMMARY: Herein, we first present a 57-year-old patient diagnosed with L/SCNEC of the stomach. A 57-year-old Chinese male presented with epigastric discomfort. Outpatient gastroscopic biopsy was performed, and pathological examination revealed that the cardia was invaded by adenocarcinoma. The patient underwent laparoscopic-assisted radical proximal subtotal gastrectomy and was diagnosed with L/SCNEC. He refused adjuvant treatment and was followed up every 3 mo. Eight months after the operation, the patient showed no evidence of local recurrence or distant metastasis. CONCLUSION: We advocate conducting further genomic studies to explore the origin of gastric large cell and small cell neuroendocrine carcinoma and using different chemotherapy schemes according to large or small cell neuroendocrine carcinoma of the stomach for clinical research to clarify the heterogeneity of GNEC and improve the prognosis of patients with GNEC.
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spelling pubmed-92108882022-07-07 Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature Li, Ze-Feng Lu, Hai-Zhen Chen, Ying-Tai Bai, Xiao-Feng Wang, Tong-Bo Fei, He Zhao, Dong-Bing World J Clin Cases Case Report BACKGROUND: Gastric neuroendocrine carcinoma (GNEC) is a rare histological subtype of gastric cancer, which is categorized into small cell and large cell neuroendocrine carcinomas. It is characterized by strong invasiveness and poor prognosis. Mixed large and small cell neuroendocrine carcinoma (L/SCNEC) is an extremely rare pathological type of gastric cancer, and there have been no reports on this situation until now. CASE SUMMARY: Herein, we first present a 57-year-old patient diagnosed with L/SCNEC of the stomach. A 57-year-old Chinese male presented with epigastric discomfort. Outpatient gastroscopic biopsy was performed, and pathological examination revealed that the cardia was invaded by adenocarcinoma. The patient underwent laparoscopic-assisted radical proximal subtotal gastrectomy and was diagnosed with L/SCNEC. He refused adjuvant treatment and was followed up every 3 mo. Eight months after the operation, the patient showed no evidence of local recurrence or distant metastasis. CONCLUSION: We advocate conducting further genomic studies to explore the origin of gastric large cell and small cell neuroendocrine carcinoma and using different chemotherapy schemes according to large or small cell neuroendocrine carcinoma of the stomach for clinical research to clarify the heterogeneity of GNEC and improve the prognosis of patients with GNEC. Baishideng Publishing Group Inc 2022-06-06 2022-06-06 /pmc/articles/PMC9210888/ /pubmed/35812663 http://dx.doi.org/10.12998/wjcc.v10.i16.5502 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Report
Li, Ze-Feng
Lu, Hai-Zhen
Chen, Ying-Tai
Bai, Xiao-Feng
Wang, Tong-Bo
Fei, He
Zhao, Dong-Bing
Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title_full Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title_fullStr Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title_full_unstemmed Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title_short Mixed large and small cell neuroendocrine carcinoma of the stomach: A case report and review of literature
title_sort mixed large and small cell neuroendocrine carcinoma of the stomach: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210888/
https://www.ncbi.nlm.nih.gov/pubmed/35812663
http://dx.doi.org/10.12998/wjcc.v10.i16.5502
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