Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir

Remdesivir and molnupiravir have gained considerable interest because of their demonstrated activity against SARS-CoV-2. These antivirals are converted intracellularly to their active triphosphate forms remdesivir-TP and molnupiravir-TP. Cellular hydrolysis of these active metabolites would conseque...

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Detalles Bibliográficos
Autores principales: Jemth, Ann-Sofie, Scaletti, Emma Rose, Homan, Evert, Stenmark, Pål, Helleday, Thomas, Michel, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212496/
https://www.ncbi.nlm.nih.gov/pubmed/35732208
http://dx.doi.org/10.1016/j.jbc.2022.102169

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