Cargando…

Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study

BACKGROUND: Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures. Such studies are scarce in Egypt, thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity. METHODS: This survey included...

Descripción completa

Detalles Bibliográficos
Autores principales: El-Ghitany, Engy Mohamed, Ashour, Ayat, Farghaly, Azza Galal, Hashish, Mona H., Omran, Eman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212586/
https://www.ncbi.nlm.nih.gov/pubmed/38013717
http://dx.doi.org/10.1016/j.imj.2022.06.003
_version_ 1784730632805416960
author El-Ghitany, Engy Mohamed
Ashour, Ayat
Farghaly, Azza Galal
Hashish, Mona H.
Omran, Eman A.
author_facet El-Ghitany, Engy Mohamed
Ashour, Ayat
Farghaly, Azza Galal
Hashish, Mona H.
Omran, Eman A.
author_sort El-Ghitany, Engy Mohamed
collection PubMed
description BACKGROUND: Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures. Such studies are scarce in Egypt, thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity. METHODS: This survey included 2919 participants from 10 Egyptian governorates. Sera were tested for SARS-CoV-2 spike (S) and nucleocapsid (N) antibodies. Univariate and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors, clinical data, and personal practices of participants. A subgroup analysis was performed to investigate the occupational risks of seropositivity. RESULTS: Seropositivity was recorded in 1564 participants (53.6%). Independent predictors of seropositivity included non-smokers (aOR = 1.817; 95% CI: 1.407–2.346, p = 0.000), having blood group A (aOR = 1.231; 95% CI: 1.016–1.493, p = 0.034), a history of COVID-19 infection (aOR = 2.997; 95% CI: 2.176–4.127, p = 0.000), COVID-19 vaccination (aOR = 4.349; 95%CI: 2.798–6.759, p = 0.000), higher crowding index (aOR = 1.229; 95% CI: 1.041–1.451, p = 0.015), anosmia and/or ageusia (aOR = 3.453; 95% CI: 2.661–4.481, p = 0.000) and history of fever (aOR = 1.269; 95% CI: 1.033–1.560, p = 0.023). Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants (aOR = 1.760; 95% CI: 1.301–2.381, p = 0.000 and aOR = 1.384; 95% CI: 1.059–1.808, p = 0.019, respectively). Additional factors showing association with seropositivity in the univariate analysis were: female gender, age group (15–39 years), higher educational level (preparatory and above), lack of environmental disinfection and having roommates at the workplace. There was a positive correlation between the titers of both antibodies. Age was weakly correlated with anti-S titer, while anti-N was significantly correlated with the number of protective measures applied by the participants. Both antibodies were significantly correlated with adult BMI, while both were significantly negatively correlated with the smoking index. CONCLUSIONS: SARS-CoV-2 seropositivity was associated with some personal and behavioral and occupation-related factors. Fever and anosmia and/or ageusia were the symptoms mostly associated with seropositivity.
format Online
Article
Text
id pubmed-9212586
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.
record_format MEDLINE/PubMed
spelling pubmed-92125862022-06-22 Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study El-Ghitany, Engy Mohamed Ashour, Ayat Farghaly, Azza Galal Hashish, Mona H. Omran, Eman A. Infectious Medicine Original Article BACKGROUND: Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures. Such studies are scarce in Egypt, thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity. METHODS: This survey included 2919 participants from 10 Egyptian governorates. Sera were tested for SARS-CoV-2 spike (S) and nucleocapsid (N) antibodies. Univariate and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors, clinical data, and personal practices of participants. A subgroup analysis was performed to investigate the occupational risks of seropositivity. RESULTS: Seropositivity was recorded in 1564 participants (53.6%). Independent predictors of seropositivity included non-smokers (aOR = 1.817; 95% CI: 1.407–2.346, p = 0.000), having blood group A (aOR = 1.231; 95% CI: 1.016–1.493, p = 0.034), a history of COVID-19 infection (aOR = 2.997; 95% CI: 2.176–4.127, p = 0.000), COVID-19 vaccination (aOR = 4.349; 95%CI: 2.798–6.759, p = 0.000), higher crowding index (aOR = 1.229; 95% CI: 1.041–1.451, p = 0.015), anosmia and/or ageusia (aOR = 3.453; 95% CI: 2.661–4.481, p = 0.000) and history of fever (aOR = 1.269; 95% CI: 1.033–1.560, p = 0.023). Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants (aOR = 1.760; 95% CI: 1.301–2.381, p = 0.000 and aOR = 1.384; 95% CI: 1.059–1.808, p = 0.019, respectively). Additional factors showing association with seropositivity in the univariate analysis were: female gender, age group (15–39 years), higher educational level (preparatory and above), lack of environmental disinfection and having roommates at the workplace. There was a positive correlation between the titers of both antibodies. Age was weakly correlated with anti-S titer, while anti-N was significantly correlated with the number of protective measures applied by the participants. Both antibodies were significantly correlated with adult BMI, while both were significantly negatively correlated with the smoking index. CONCLUSIONS: SARS-CoV-2 seropositivity was associated with some personal and behavioral and occupation-related factors. Fever and anosmia and/or ageusia were the symptoms mostly associated with seropositivity. The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press. 2022-06 2022-06-17 /pmc/articles/PMC9212586/ /pubmed/38013717 http://dx.doi.org/10.1016/j.imj.2022.06.003 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
El-Ghitany, Engy Mohamed
Ashour, Ayat
Farghaly, Azza Galal
Hashish, Mona H.
Omran, Eman A.
Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title_full Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title_fullStr Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title_full_unstemmed Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title_short Predictors of anti-SARS-CoV-2 seropositivity: An Egyptian population-based study
title_sort predictors of anti-sars-cov-2 seropositivity: an egyptian population-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212586/
https://www.ncbi.nlm.nih.gov/pubmed/38013717
http://dx.doi.org/10.1016/j.imj.2022.06.003
work_keys_str_mv AT elghitanyengymohamed predictorsofantisarscov2seropositivityanegyptianpopulationbasedstudy
AT ashourayat predictorsofantisarscov2seropositivityanegyptianpopulationbasedstudy
AT farghalyazzagalal predictorsofantisarscov2seropositivityanegyptianpopulationbasedstudy
AT hashishmonah predictorsofantisarscov2seropositivityanegyptianpopulationbasedstudy
AT omranemana predictorsofantisarscov2seropositivityanegyptianpopulationbasedstudy