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Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital

INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positi...

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Autores principales: Nguyen, Phung Nguyen The, Thuc, Tran Thanh, Hung, Nguyen Thanh, Thinh, Le Quoc, Minh, Ngo Ngoc Quang, Duy, Dang Quoc, Nhut, Tran Minh, Linh, Nguyen Bich Y, Tuan, Tran Minh, Giang, Ngo Hoang Lam, Tuyen, Vo Thi Minh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212605/
https://www.ncbi.nlm.nih.gov/pubmed/35738340
http://dx.doi.org/10.1016/j.jiac.2022.06.010
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author Nguyen, Phung Nguyen The
Thuc, Tran Thanh
Hung, Nguyen Thanh
Thinh, Le Quoc
Minh, Ngo Ngoc Quang
Duy, Dang Quoc
Nhut, Tran Minh
Linh, Nguyen Bich Y
Tuan, Tran Minh
Giang, Ngo Hoang Lam
Tuyen, Vo Thi Minh
author_facet Nguyen, Phung Nguyen The
Thuc, Tran Thanh
Hung, Nguyen Thanh
Thinh, Le Quoc
Minh, Ngo Ngoc Quang
Duy, Dang Quoc
Nhut, Tran Minh
Linh, Nguyen Bich Y
Tuan, Tran Minh
Giang, Ngo Hoang Lam
Tuyen, Vo Thi Minh
author_sort Nguyen, Phung Nguyen The
collection PubMed
description INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included. RESULTS: Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73,7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment. CONCLUSIONS: In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases.
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spelling pubmed-92126052022-06-22 Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital Nguyen, Phung Nguyen The Thuc, Tran Thanh Hung, Nguyen Thanh Thinh, Le Quoc Minh, Ngo Ngoc Quang Duy, Dang Quoc Nhut, Tran Minh Linh, Nguyen Bich Y Tuan, Tran Minh Giang, Ngo Hoang Lam Tuyen, Vo Thi Minh J Infect Chemother Original Article INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included. RESULTS: Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73,7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment. CONCLUSIONS: In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022-10 2022-06-20 /pmc/articles/PMC9212605/ /pubmed/35738340 http://dx.doi.org/10.1016/j.jiac.2022.06.010 Text en © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Nguyen, Phung Nguyen The
Thuc, Tran Thanh
Hung, Nguyen Thanh
Thinh, Le Quoc
Minh, Ngo Ngoc Quang
Duy, Dang Quoc
Nhut, Tran Minh
Linh, Nguyen Bich Y
Tuan, Tran Minh
Giang, Ngo Hoang Lam
Tuyen, Vo Thi Minh
Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title_full Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title_fullStr Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title_full_unstemmed Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title_short Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
title_sort risk factors for disease severity and mortality of children with covid-19: a study at a vietnamese children's hospital
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212605/
https://www.ncbi.nlm.nih.gov/pubmed/35738340
http://dx.doi.org/10.1016/j.jiac.2022.06.010
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