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Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital
INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212605/ https://www.ncbi.nlm.nih.gov/pubmed/35738340 http://dx.doi.org/10.1016/j.jiac.2022.06.010 |
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author | Nguyen, Phung Nguyen The Thuc, Tran Thanh Hung, Nguyen Thanh Thinh, Le Quoc Minh, Ngo Ngoc Quang Duy, Dang Quoc Nhut, Tran Minh Linh, Nguyen Bich Y Tuan, Tran Minh Giang, Ngo Hoang Lam Tuyen, Vo Thi Minh |
author_facet | Nguyen, Phung Nguyen The Thuc, Tran Thanh Hung, Nguyen Thanh Thinh, Le Quoc Minh, Ngo Ngoc Quang Duy, Dang Quoc Nhut, Tran Minh Linh, Nguyen Bich Y Tuan, Tran Minh Giang, Ngo Hoang Lam Tuyen, Vo Thi Minh |
author_sort | Nguyen, Phung Nguyen The |
collection | PubMed |
description | INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included. RESULTS: Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73,7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment. CONCLUSIONS: In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases. |
format | Online Article Text |
id | pubmed-9212605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92126052022-06-22 Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital Nguyen, Phung Nguyen The Thuc, Tran Thanh Hung, Nguyen Thanh Thinh, Le Quoc Minh, Ngo Ngoc Quang Duy, Dang Quoc Nhut, Tran Minh Linh, Nguyen Bich Y Tuan, Tran Minh Giang, Ngo Hoang Lam Tuyen, Vo Thi Minh J Infect Chemother Original Article INTRODUCTION: To find out risk factors for disease severity and mortality of pediatric COVID-19 in the fourth wave of COVID-19 in Vietnam. METHODS: This retrospective cohort study was performed at Children's Hospital 1 from July to December 2021. All children with COVID-19 confirmed by a positive Realtime RT-PCR SARS-CoV-2 result and treated at COVID-19 department for at least 72 h were included. RESULTS: Of the 850 cases admitting to COVID-19 department, 555 children with COVID-19 confirmed by positive RT-PCR and treated at our center for more than 72 h. Median age of confirmed cases was 22.3 (IQR: 3.2–88.6) months, 55.1% were male, and 84.5% had a history of close contact with confirmed COVID-19 patients. The rate of mild, moderate and severe/critical cases was 73,7%, 9.0% and 17.3%, respectively. One hundred ninety-two children (34.6%) had underlying diseases, in which, neurologic disease was the most common underlying disease (7.9%). Underlying disease, dyspnea, elevated CRP >20 mg/L and elevated ferritin were independent factors related to severe illness. Twenty-point two percent of patients in our study needed respiratory support, including 22 invasive mechanical ventilation cases. Eighteen cases (3.2%) died because of severe comorbidities, poor response to treatment. CONCLUSIONS: In our study, the severe/critical and mortality rates in pediatric COVID-19 cases were relatively high. All fatal cases had severe comorbidities. Underlying disease, dyspnea, and elevated inflammatory markers were independent factors related to severity in pediatric COVID-19 cases. Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. 2022-10 2022-06-20 /pmc/articles/PMC9212605/ /pubmed/35738340 http://dx.doi.org/10.1016/j.jiac.2022.06.010 Text en © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Nguyen, Phung Nguyen The Thuc, Tran Thanh Hung, Nguyen Thanh Thinh, Le Quoc Minh, Ngo Ngoc Quang Duy, Dang Quoc Nhut, Tran Minh Linh, Nguyen Bich Y Tuan, Tran Minh Giang, Ngo Hoang Lam Tuyen, Vo Thi Minh Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title | Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title_full | Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title_fullStr | Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title_full_unstemmed | Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title_short | Risk factors for disease severity and mortality of children with Covid-19: A study at a Vietnamese Children's hospital |
title_sort | risk factors for disease severity and mortality of children with covid-19: a study at a vietnamese children's hospital |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212605/ https://www.ncbi.nlm.nih.gov/pubmed/35738340 http://dx.doi.org/10.1016/j.jiac.2022.06.010 |
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