The Role of Podoplanin in the Immune System and Inflammation

Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation....

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Detalles Bibliográficos
Autores principales: Zhang, Zhiyuan, Zhang, Nan, Yu, Jing, Xu, Wenting, Gao, Jiameng, Lv, Xin, Wen, Zongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212786/
https://www.ncbi.nlm.nih.gov/pubmed/35747250
http://dx.doi.org/10.2147/JIR.S366620
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author Zhang, Zhiyuan
Zhang, Nan
Yu, Jing
Xu, Wenting
Gao, Jiameng
Lv, Xin
Wen, Zongmei
author_facet Zhang, Zhiyuan
Zhang, Nan
Yu, Jing
Xu, Wenting
Gao, Jiameng
Lv, Xin
Wen, Zongmei
author_sort Zhang, Zhiyuan
collection PubMed
description Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases.
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spelling pubmed-92127862022-06-22 The Role of Podoplanin in the Immune System and Inflammation Zhang, Zhiyuan Zhang, Nan Yu, Jing Xu, Wenting Gao, Jiameng Lv, Xin Wen, Zongmei J Inflamm Res Review Podoplanin is a small cell-surface mucin-like glycoprotein that participates in multiple physiological and pathological processes. Podoplanin exerts an important function in the immune response and is upregulated in fibroblasts, macrophages, T helper cells, and epithelial cells during inflammation. Herein, we summarize the latest knowledge on the functional expression of podoplanin in the immune system and review the contribution of podoplanin to several inflammatory diseases. Furthermore, we discuss podoplanin as a novel therapeutic target for various inflammatory diseases. Dove 2022-06-17 /pmc/articles/PMC9212786/ /pubmed/35747250 http://dx.doi.org/10.2147/JIR.S366620 Text en © 2022 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhang, Zhiyuan
Zhang, Nan
Yu, Jing
Xu, Wenting
Gao, Jiameng
Lv, Xin
Wen, Zongmei
The Role of Podoplanin in the Immune System and Inflammation
title The Role of Podoplanin in the Immune System and Inflammation
title_full The Role of Podoplanin in the Immune System and Inflammation
title_fullStr The Role of Podoplanin in the Immune System and Inflammation
title_full_unstemmed The Role of Podoplanin in the Immune System and Inflammation
title_short The Role of Podoplanin in the Immune System and Inflammation
title_sort role of podoplanin in the immune system and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212786/
https://www.ncbi.nlm.nih.gov/pubmed/35747250
http://dx.doi.org/10.2147/JIR.S366620
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