Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation

Since the discovery of oncogenes, there has been tremendous interest to understand their mechanistic basis and to develop broadly actionable therapeutics. Some of the most frequently activated oncogenes driving diverse cancers are c-MYC, EGFR, HER2, AKT, KRAS, BRAF, and MEK. Using a reductionist app...

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Detalles Bibliográficos
Autores principales: Solomon, Paige E., Kirkemo, Lisa L., Wilson, Gary M., Leung, Kevin K., Almond, Mark H., Sayles, Leanne C., Sweet-Cordero, E. Alejandro, Rosenberg, Oren S., Coon, Joshua J., Wells, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9212846/
https://www.ncbi.nlm.nih.gov/pubmed/35594991
http://dx.doi.org/10.1016/j.mcpro.2022.100247

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