Blood flow meets mitophagy

Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustai...

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Detalles Bibliográficos
Autores principales: Akmeriç, Emir Bora, Gerhardt, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213090/
https://www.ncbi.nlm.nih.gov/pubmed/35727256
http://dx.doi.org/10.1083/jcb.202206033
Descripción
Sumario:Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2’s transcriptional dynamics.

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