Cargando…
Blood flow meets mitophagy
Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustai...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213090/ https://www.ncbi.nlm.nih.gov/pubmed/35727256 http://dx.doi.org/10.1083/jcb.202206033 |
Sumario: | Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2’s transcriptional dynamics. |
---|