Blood flow meets mitophagy

Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustai...

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Detalles Bibliográficos
Autores principales: Akmeriç, Emir Bora, Gerhardt, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213090/
https://www.ncbi.nlm.nih.gov/pubmed/35727256
http://dx.doi.org/10.1083/jcb.202206033
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author Akmeriç, Emir Bora
Gerhardt, Holger
author_facet Akmeriç, Emir Bora
Gerhardt, Holger
author_sort Akmeriç, Emir Bora
collection PubMed
description Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2’s transcriptional dynamics.
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spelling pubmed-92130902023-01-04 Blood flow meets mitophagy Akmeriç, Emir Bora Gerhardt, Holger J Cell Biol Spotlight Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2’s varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2’s transcriptional dynamics. Rockefeller University Press 2022-04-20 /pmc/articles/PMC9213090/ /pubmed/35727256 http://dx.doi.org/10.1083/jcb.202206033 Text en © 2022 Akmeriç and Gerhardt https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Akmeriç, Emir Bora
Gerhardt, Holger
Blood flow meets mitophagy
title Blood flow meets mitophagy
title_full Blood flow meets mitophagy
title_fullStr Blood flow meets mitophagy
title_full_unstemmed Blood flow meets mitophagy
title_short Blood flow meets mitophagy
title_sort blood flow meets mitophagy
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213090/
https://www.ncbi.nlm.nih.gov/pubmed/35727256
http://dx.doi.org/10.1083/jcb.202206033
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