Cargando…

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans

BACKGROUND: Resistance to antifungal drugs for treating Candida infections remains a major concern globally despite the range of medications available. Most of these drugs target key proteins essential to the life cycle of the organism. An enzyme essential for fungal cell membrane integrity, lanoste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Odiba, Arome Solomon, Durojaye, Olanrewaju Ayodeji, Ezeonu, Ifeoma Maureen, Mgbeahuruike, Anthony Christian, Nwanguma, Bennett Chima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213107/ https://www.ncbi.nlm.nih.gov/pubmed/35747333 http://dx.doi.org/10.2147/IDR.S360973

Ejemplares similares

MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference
por: Durojaye, Olanrewaju Ayodeji, et al.
Publicado: (2023)

Characterization of the SARS-CoV-2 coronavirus X4-like accessory protein
por: Durojaye, Olanrewaju Ayodeji, et al.
Publicado: (2021)

Gene therapy in PIDs, hemoglobin, ocular, neurodegenerative, and hemophilia B disorders
por: Odiba, Arome Solomon, et al.
Publicado: (2021)

Detection of ERG11 point mutations in Iranian fluconazole-resistant Candida albicans isolates
por: Sardari, Ali, et al.
Publicado: (2019)

The Role of ERG11 Point Mutations in the Resistance of Candida albicans to Fluconazole in the Presence of Lactate
por: Urbanek, Aneta K., et al.
Publicado: (2022)

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates
por: M.S., Sheena, et al.
Publicado: (2022)

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans
por: Alizadeh, F, et al.
Publicado: (2017)

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients
por: Paul, Sony, et al.
Publicado: (2019)

Computational insights into fluconazole resistance by the suspected mutations in lanosterol 14α-demethylase (Erg11p) of Candida albicans
por: Prakash, Sagunthala Murugesan Udaya, et al.
Publicado: (2020)

Effect of biogenic selenium nanoparticles on ERG11 and CDR1 gene expression in both fluconazole-resistant and -susceptible Candida albicans isolates
por: Parsameher, Nasrin, et al.
Publicado: (2017)

Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing
por: Wang, Huiping, et al.
Publicado: (2009)

Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole
por: Li, Xiuyun, et al.
Publicado: (2017)

Investigation of fluconazole susceptibility to Candida albicans by MALDI-TOF MS and real-time PCR for CDR1, CDR2, MDR1 and ERG11
por: Maenchantrarath, Chanika, et al.
Publicado: (2022)

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection
por: Zhou, Yujie, et al.
Publicado: (2018)

Fluconazole impacts the extracellular matrix of fluconazole-susceptible and -resistant Candida albicans and Candida glabrata biofilms
por: Panariello, Beatriz Helena Dias, et al.
Publicado: (2018)

The Synergism of the Small Molecule ENOblock and Fluconazole Against Fluconazole-Resistant Candida albicans
por: Li, Liping, et al.
Publicado: (2019)

Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida albicans, Candida tropicalis, and Fluconazole-Resistant Strains
por: Lo, Wei-Hsuan, et al.
Publicado: (2020)

Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
por: Delarze, Eric, et al.
Publicado: (2020)

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species
por: Locke, Jeffrey B., et al.
Publicado: (2018)

Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea
por: Choi, Yong Jun, et al.
Publicado: (2018)

Glutathione Metabolism in Candida albicans Resistant Strains to Fluconazole and Micafungin
por: Maras, Bruno, et al.
Publicado: (2014)

Biofilm Formation and Susceptibility to Amphotericin B and Fluconazole in Candida albicans
por: Zarei Mahmoudabadi, Ali, et al.
Publicado: (2014)

Susceptibility of Fluconazole-Resistant Candida albicans to Thyme Essential Oil
por: Alshaikh, Najla A, et al.
Publicado: (2021)

Mathematical Modeling of Fluconazole Resistance in the Ergosterol Pathway of Candida albicans
por: Yu, Paul K., et al.
Publicado: (2022)

Genome-wide translational response of Candida albicans to fluconazole treatment
por: Choudhary, Saket, et al.
Publicado: (2023)

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates
por: Jin, Longyang, et al.
Publicado: (2018)

Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes
por: Dekkerová, Jaroslava, et al.
Publicado: (2022)

Novel hydroxamates potentiated in vitro activity of fluconazole against Candida albicans
por: Paul-Satyaseela, Maneesh, et al.
Publicado: (2017)

Fluconazole resistance in Candida albicans is induced by Pseudomonas aeruginosa quorum sensing
por: Bandara, H. M. H. N., et al.
Publicado: (2020)

Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress
por: Hunsaker, Elizabeth W, et al.
Publicado: (2021)

Biofilm Alterations on the Stepwise Acquisition of Fluconazole-resistant Candida Albicans Isolates
por: Song, Na-Na, et al.
Publicado: (2022)

Zerumbone Disturbs the Extracellular Matrix of Fluconazole-Resistant Candida albicans Biofilms
por: Abreu-Pereira, César Augusto, et al.
Publicado: (2023)

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence
por: Villasmil, Michelle L., et al.
Publicado: (2020)

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso
por: Dovo, Essi Etonam, et al.
Publicado: (2022)

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains
por: Mertas, Anna, et al.
Publicado: (2015)

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates
por: Xu, Yi, et al.
Publicado: (2017)

Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump
por: Xu, Jiali, et al.
Publicado: (2019)

Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans
por: Sharifzadeh, Aghil, et al.
Publicado: (2016)

Post-antifungal effect of the combination of anidulafungin with amphotericin B and fluconazole against fluconazole-susceptible and -resistant Candida albicans
por: Vaseghi, Narges, et al.
Publicado: (2022)

A chromosome 4 trisomy contributes to increased fluconazole resistance in a clinical isolate of Candida albicans
por: Anderson, Matthew Z., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e00ev1hdjdo8ng0d9ld4nr1ku1