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Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia

PURPOSE: To observe the clinical efficacy of Reduning injection combined with recombinant human interferon α-2b spray in the treatment of children with viral pneumonia. METHODS: A total of 200 children with viral pneumonia over 2 years old who were admitted to the Pediatrics Department of the Cangzh...

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Autores principales: Li, Zhuangzhuang, Xie, Lingling, Wang, He, Wang, Shugen, Wu, Jinguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213134/
https://www.ncbi.nlm.nih.gov/pubmed/35747380
http://dx.doi.org/10.1155/2022/1739561
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author Li, Zhuangzhuang
Xie, Lingling
Wang, He
Wang, Shugen
Wu, Jinguang
author_facet Li, Zhuangzhuang
Xie, Lingling
Wang, He
Wang, Shugen
Wu, Jinguang
author_sort Li, Zhuangzhuang
collection PubMed
description PURPOSE: To observe the clinical efficacy of Reduning injection combined with recombinant human interferon α-2b spray in the treatment of children with viral pneumonia. METHODS: A total of 200 children with viral pneumonia over 2 years old who were admitted to the Pediatrics Department of the Cangzhou Central Hospital from September 2018 to November 2020 were recruited and randomized into the control group and observation group at a ratio of 1 : 1, with 100 cases in each group. The children in the control group were given recombinant human interferon α-2b spray, and the children in the observation group were given Reduning injection on the basis of the control group. The clinical symptoms and signs, clinical efficacy, levels of inflammatory mediators, and drug safety were compared between the two groups. RESULTS: The t-test results showed that the disappearance time of body temperature, respiratory rate, pulmonary rales, and cough in the observation group was significantly shorter than that in the control group. The chi-square revealed a significantly higher total effective rate in the observation group vs. the control group. After treatment, the levels of IL-1, IL-6, TNF-α, and CRP in the two groups were lower than the corresponding values before treatment, and greater reduction was observed in the observation group in relative to the control group (both p < 0.05). The two groups have a similar safety profile. CONCLUSION: Reduning combined with recombinant human interferon α-2b produces a remarkable effect in the treatment of children with viral pneumonia, and it ameliorates clinical symptoms and reduces inflammatory response with a good safety profile.
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spelling pubmed-92131342022-06-22 Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia Li, Zhuangzhuang Xie, Lingling Wang, He Wang, Shugen Wu, Jinguang Evid Based Complement Alternat Med Research Article PURPOSE: To observe the clinical efficacy of Reduning injection combined with recombinant human interferon α-2b spray in the treatment of children with viral pneumonia. METHODS: A total of 200 children with viral pneumonia over 2 years old who were admitted to the Pediatrics Department of the Cangzhou Central Hospital from September 2018 to November 2020 were recruited and randomized into the control group and observation group at a ratio of 1 : 1, with 100 cases in each group. The children in the control group were given recombinant human interferon α-2b spray, and the children in the observation group were given Reduning injection on the basis of the control group. The clinical symptoms and signs, clinical efficacy, levels of inflammatory mediators, and drug safety were compared between the two groups. RESULTS: The t-test results showed that the disappearance time of body temperature, respiratory rate, pulmonary rales, and cough in the observation group was significantly shorter than that in the control group. The chi-square revealed a significantly higher total effective rate in the observation group vs. the control group. After treatment, the levels of IL-1, IL-6, TNF-α, and CRP in the two groups were lower than the corresponding values before treatment, and greater reduction was observed in the observation group in relative to the control group (both p < 0.05). The two groups have a similar safety profile. CONCLUSION: Reduning combined with recombinant human interferon α-2b produces a remarkable effect in the treatment of children with viral pneumonia, and it ameliorates clinical symptoms and reduces inflammatory response with a good safety profile. Hindawi 2022-06-14 /pmc/articles/PMC9213134/ /pubmed/35747380 http://dx.doi.org/10.1155/2022/1739561 Text en Copyright © 2022 Zhuangzhuang Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Zhuangzhuang
Xie, Lingling
Wang, He
Wang, Shugen
Wu, Jinguang
Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title_full Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title_fullStr Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title_full_unstemmed Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title_short Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia
title_sort clinical observation of reduning combined with recombinant human interferon α-2b in the treatment of children with viral pneumonia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213134/
https://www.ncbi.nlm.nih.gov/pubmed/35747380
http://dx.doi.org/10.1155/2022/1739561
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