Biofortified tomatoes provide a new route to vitamin D sufficiency

Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D(3) in tomato by genome editing, m...

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Autores principales: Li, Jie, Scarano, Aurelia, Gonzalez, Nestor Mora, D’Orso, Fabio, Yue, Yajuan, Nemeth, Krisztian, Saalbach, Gerhard, Hill, Lionel, de Oliveira Martins, Carlo, Moran, Rolando, Santino, Angelo, Martin, Cathie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213236/
https://www.ncbi.nlm.nih.gov/pubmed/35606499
http://dx.doi.org/10.1038/s41477-022-01154-6
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author Li, Jie
Scarano, Aurelia
Gonzalez, Nestor Mora
D’Orso, Fabio
Yue, Yajuan
Nemeth, Krisztian
Saalbach, Gerhard
Hill, Lionel
de Oliveira Martins, Carlo
Moran, Rolando
Santino, Angelo
Martin, Cathie
author_facet Li, Jie
Scarano, Aurelia
Gonzalez, Nestor Mora
D’Orso, Fabio
Yue, Yajuan
Nemeth, Krisztian
Saalbach, Gerhard
Hill, Lionel
de Oliveira Martins, Carlo
Moran, Rolando
Santino, Angelo
Martin, Cathie
author_sort Li, Jie
collection PubMed
description Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D(3) in tomato by genome editing, modifying a duplicated section of phytosterol biosynthesis in Solanaceous plants, to provide a biofortified food with the added possibility of supplement production from waste material.
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spelling pubmed-92132362022-06-23 Biofortified tomatoes provide a new route to vitamin D sufficiency Li, Jie Scarano, Aurelia Gonzalez, Nestor Mora D’Orso, Fabio Yue, Yajuan Nemeth, Krisztian Saalbach, Gerhard Hill, Lionel de Oliveira Martins, Carlo Moran, Rolando Santino, Angelo Martin, Cathie Nat Plants Brief Communication Poor vitamin D status is a global health problem; insufficiency underpins higher risk of cancer, neurocognitive decline and all-cause mortality. Most foods contain little vitamin D and plants are very poor sources. We have engineered the accumulation of provitamin D(3) in tomato by genome editing, modifying a duplicated section of phytosterol biosynthesis in Solanaceous plants, to provide a biofortified food with the added possibility of supplement production from waste material. Nature Publishing Group UK 2022-05-23 2022 /pmc/articles/PMC9213236/ /pubmed/35606499 http://dx.doi.org/10.1038/s41477-022-01154-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Li, Jie
Scarano, Aurelia
Gonzalez, Nestor Mora
D’Orso, Fabio
Yue, Yajuan
Nemeth, Krisztian
Saalbach, Gerhard
Hill, Lionel
de Oliveira Martins, Carlo
Moran, Rolando
Santino, Angelo
Martin, Cathie
Biofortified tomatoes provide a new route to vitamin D sufficiency
title Biofortified tomatoes provide a new route to vitamin D sufficiency
title_full Biofortified tomatoes provide a new route to vitamin D sufficiency
title_fullStr Biofortified tomatoes provide a new route to vitamin D sufficiency
title_full_unstemmed Biofortified tomatoes provide a new route to vitamin D sufficiency
title_short Biofortified tomatoes provide a new route to vitamin D sufficiency
title_sort biofortified tomatoes provide a new route to vitamin d sufficiency
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213236/
https://www.ncbi.nlm.nih.gov/pubmed/35606499
http://dx.doi.org/10.1038/s41477-022-01154-6
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