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Maintaining the thyroid gland in mutant thyroglobulin–induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood

Congenital hypothyroidism with biallelic thyroglobulin (Tg protein, encoded by the TG gene) mutation is an endoplasmic reticulum (ER) storage disease. Many patients (and animal models) grow an enlarged thyroid (goiter), yet some do not. In adulthood, hypothyroid TG(cog/cog) mice (bearing a Tg-L2263P...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiaohan, Malik, Bhoomanyu, Young, Crystal, Zhang, Hao, Larkin, Dennis, Liao, Xiao-Hui, Refetoff, Samuel, Liu, Ming, Arvan, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213252/ https://www.ncbi.nlm.nih.gov/pubmed/35618019 http://dx.doi.org/10.1016/j.jbc.2022.102066

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