Cargando…

Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)

INTRODUCTION: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB)....

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Mirella, Carrarini, Claudia, Di Iorio, Angelo, Pellegrino, Raffaello, Bruni, Amalia Cecilia, Caratozzolo, Salvatore, Chiari, Annalisa, Pretta, Stefano, Marra, Camillo, Cotelli, Maria Sofia, Arighi, Andrea, Fumagalli, Giorgio G., Cataruzza, Tatiana, Caso, Francesca, Paci, Cristina, Rosso, Mara, Amici, Serena, Giannandrea, David, Pilotto, Andrea, Luzzi, Simona, Castellano, Annalisa, D’antonio, Fabrizia, Luca, Antonina, Gelosa, Giorgio, Piccoli, Tommaso, Mauri, Marco, Agosta, Federica, Babiloni, Claudio, Borroni, Barbara, Bozzali, Marco, Filippi, Massimo, Galimberti, Daniela, Monastero, Roberto, Muscio, Cristina, Parnetti, Lucilla, Perani, Daniela, Serra, Laura, Silani, Vincenzo, Tiraboschi, Pietro, Cagnin, Annachiara, Padovani, Alessandro, Bonanni, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213280/
https://www.ncbi.nlm.nih.gov/pubmed/35244829
http://dx.doi.org/10.1007/s10072-022-05987-z
_version_ 1784730806917267456
author Russo, Mirella
Carrarini, Claudia
Di Iorio, Angelo
Pellegrino, Raffaello
Bruni, Amalia Cecilia
Caratozzolo, Salvatore
Chiari, Annalisa
Pretta, Stefano
Marra, Camillo
Cotelli, Maria Sofia
Arighi, Andrea
Fumagalli, Giorgio G.
Cataruzza, Tatiana
Caso, Francesca
Paci, Cristina
Rosso, Mara
Amici, Serena
Giannandrea, David
Pilotto, Andrea
Luzzi, Simona
Castellano, Annalisa
D’antonio, Fabrizia
Luca, Antonina
Gelosa, Giorgio
Piccoli, Tommaso
Mauri, Marco
Agosta, Federica
Babiloni, Claudio
Borroni, Barbara
Bozzali, Marco
Filippi, Massimo
Galimberti, Daniela
Monastero, Roberto
Muscio, Cristina
Parnetti, Lucilla
Perani, Daniela
Serra, Laura
Silani, Vincenzo
Tiraboschi, Pietro
Cagnin, Annachiara
Padovani, Alessandro
Bonanni, Laura
author_facet Russo, Mirella
Carrarini, Claudia
Di Iorio, Angelo
Pellegrino, Raffaello
Bruni, Amalia Cecilia
Caratozzolo, Salvatore
Chiari, Annalisa
Pretta, Stefano
Marra, Camillo
Cotelli, Maria Sofia
Arighi, Andrea
Fumagalli, Giorgio G.
Cataruzza, Tatiana
Caso, Francesca
Paci, Cristina
Rosso, Mara
Amici, Serena
Giannandrea, David
Pilotto, Andrea
Luzzi, Simona
Castellano, Annalisa
D’antonio, Fabrizia
Luca, Antonina
Gelosa, Giorgio
Piccoli, Tommaso
Mauri, Marco
Agosta, Federica
Babiloni, Claudio
Borroni, Barbara
Bozzali, Marco
Filippi, Massimo
Galimberti, Daniela
Monastero, Roberto
Muscio, Cristina
Parnetti, Lucilla
Perani, Daniela
Serra, Laura
Silani, Vincenzo
Tiraboschi, Pietro
Cagnin, Annachiara
Padovani, Alessandro
Bonanni, Laura
author_sort Russo, Mirella
collection PubMed
description INTRODUCTION: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria. METHODS: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3 months. We asked to subsequently apply consensus criteria for DLB diagnosis, to validate the diagnostic accuracy of the two toolkits. RESULTS: A total of 23 Centers joined the study; 1854 patients were enrolled. We found a prevalence of possible or probable DLB of 13% each (26% total), according to the consensus criteria. LBCRS toolkit showed good reliability, with a Cronbach alpha of 0.77, stable even after removing variables from the construct. AT-DLB toolkit Cronbach alpha was 0.52 and, after the subtraction of the “cognitive fluctuation” criterion, was only 0.31. Accuracy, sensitivity, and specificity were higher for LBCRS vs. AT-DLB. However, when simultaneously considered in the logistic models, AT-DLB showed a better performance (p < 0.001). Overall, the concordance between LBCRS positive and AT-DLB possible/probable was of 78.02% CONCLUSIONS: In a clinical setting, the LBCRS and AT-DLB questionnaires have good accuracy for DLB diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-022-05987-z.
format Online
Article
Text
id pubmed-9213280
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-92132802022-06-23 Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem) Russo, Mirella Carrarini, Claudia Di Iorio, Angelo Pellegrino, Raffaello Bruni, Amalia Cecilia Caratozzolo, Salvatore Chiari, Annalisa Pretta, Stefano Marra, Camillo Cotelli, Maria Sofia Arighi, Andrea Fumagalli, Giorgio G. Cataruzza, Tatiana Caso, Francesca Paci, Cristina Rosso, Mara Amici, Serena Giannandrea, David Pilotto, Andrea Luzzi, Simona Castellano, Annalisa D’antonio, Fabrizia Luca, Antonina Gelosa, Giorgio Piccoli, Tommaso Mauri, Marco Agosta, Federica Babiloni, Claudio Borroni, Barbara Bozzali, Marco Filippi, Massimo Galimberti, Daniela Monastero, Roberto Muscio, Cristina Parnetti, Lucilla Perani, Daniela Serra, Laura Silani, Vincenzo Tiraboschi, Pietro Cagnin, Annachiara Padovani, Alessandro Bonanni, Laura Neurol Sci Original Article INTRODUCTION: Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Body Composite Risk Score (LBCRS) and the Assessment Toolkit for DLB (AT-DLB). We aim to evaluate the reliability of these two questionnaires, and their ability to enhance the interpretation of the international consensus diagnostic criteria. METHODS: LBCRS and AT-DLB were distributed to 135 Italian Neurological Centers for Cognitive Decline and Dementia (CDCDs), with the indication to administer them to all patients with dementia referred within the subsequent 3 months. We asked to subsequently apply consensus criteria for DLB diagnosis, to validate the diagnostic accuracy of the two toolkits. RESULTS: A total of 23 Centers joined the study; 1854 patients were enrolled. We found a prevalence of possible or probable DLB of 13% each (26% total), according to the consensus criteria. LBCRS toolkit showed good reliability, with a Cronbach alpha of 0.77, stable even after removing variables from the construct. AT-DLB toolkit Cronbach alpha was 0.52 and, after the subtraction of the “cognitive fluctuation” criterion, was only 0.31. Accuracy, sensitivity, and specificity were higher for LBCRS vs. AT-DLB. However, when simultaneously considered in the logistic models, AT-DLB showed a better performance (p < 0.001). Overall, the concordance between LBCRS positive and AT-DLB possible/probable was of 78.02% CONCLUSIONS: In a clinical setting, the LBCRS and AT-DLB questionnaires have good accuracy for DLB diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10072-022-05987-z. Springer International Publishing 2022-03-04 2022 /pmc/articles/PMC9213280/ /pubmed/35244829 http://dx.doi.org/10.1007/s10072-022-05987-z Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Russo, Mirella
Carrarini, Claudia
Di Iorio, Angelo
Pellegrino, Raffaello
Bruni, Amalia Cecilia
Caratozzolo, Salvatore
Chiari, Annalisa
Pretta, Stefano
Marra, Camillo
Cotelli, Maria Sofia
Arighi, Andrea
Fumagalli, Giorgio G.
Cataruzza, Tatiana
Caso, Francesca
Paci, Cristina
Rosso, Mara
Amici, Serena
Giannandrea, David
Pilotto, Andrea
Luzzi, Simona
Castellano, Annalisa
D’antonio, Fabrizia
Luca, Antonina
Gelosa, Giorgio
Piccoli, Tommaso
Mauri, Marco
Agosta, Federica
Babiloni, Claudio
Borroni, Barbara
Bozzali, Marco
Filippi, Massimo
Galimberti, Daniela
Monastero, Roberto
Muscio, Cristina
Parnetti, Lucilla
Perani, Daniela
Serra, Laura
Silani, Vincenzo
Tiraboschi, Pietro
Cagnin, Annachiara
Padovani, Alessandro
Bonanni, Laura
Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title_full Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title_fullStr Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title_full_unstemmed Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title_short Accuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
title_sort accuracy of the clinical diagnosis of dementia with lewy bodies (dlb) among the italian dementia centers: a study by the italian dlb study group (dlb-sindem)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213280/
https://www.ncbi.nlm.nih.gov/pubmed/35244829
http://dx.doi.org/10.1007/s10072-022-05987-z
work_keys_str_mv AT russomirella accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT carrariniclaudia accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT diiorioangelo accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT pellegrinoraffaello accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT bruniamaliacecilia accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT caratozzolosalvatore accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT chiariannalisa accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT prettastefano accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT marracamillo accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT cotellimariasofia accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT arighiandrea accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT fumagalligiorgiog accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT cataruzzatatiana accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT casofrancesca accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT pacicristina accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT rossomara accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT amiciserena accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT giannandreadavid accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT pilottoandrea accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT luzzisimona accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT castellanoannalisa accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT dantoniofabrizia accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT lucaantonina accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT gelosagiorgio accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT piccolitommaso accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT maurimarco accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT agostafederica accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT babiloniclaudio accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT borronibarbara accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT bozzalimarco accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT filippimassimo accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT galimbertidaniela accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT monasteroroberto accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT musciocristina accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT parnettilucilla accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT peranidaniela accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT serralaura accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT silanivincenzo accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT tiraboschipietro accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT cagninannachiara accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT padovanialessandro accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT bonannilaura accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem
AT accuracyoftheclinicaldiagnosisofdementiawithlewybodiesdlbamongtheitaliandementiacentersastudybytheitaliandlbstudygroupdlbsindem