Cargando…

Anagrelide-Induced Supraventricular Tachycardia: A Case Report

Anagrelide is an inhibitor of the phosphodiesterase-3 (PDE-3) enzyme that suppresses megakaryocytes; hence it is used in the treatment of essential thrombocythemia. Anagrelide can cause positive inotropic and chronotropic effects on the cardiovascular system. Its cardiovascular side effects are rare...

Descripción completa

Detalles Bibliográficos
Autores principales: Badar, Faraz, Azeez, Hayder, Abdulrahman, Zeinab, Ashraf, Aqsa, Iftikhar, Asma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213328/
https://www.ncbi.nlm.nih.gov/pubmed/35747119
http://dx.doi.org/10.7759/cureus.26119
_version_ 1784730818297462784
author Badar, Faraz
Azeez, Hayder
Abdulrahman, Zeinab
Ashraf, Aqsa
Iftikhar, Asma
author_facet Badar, Faraz
Azeez, Hayder
Abdulrahman, Zeinab
Ashraf, Aqsa
Iftikhar, Asma
author_sort Badar, Faraz
collection PubMed
description Anagrelide is an inhibitor of the phosphodiesterase-3 (PDE-3) enzyme that suppresses megakaryocytes; hence it is used in the treatment of essential thrombocythemia. Anagrelide can cause positive inotropic and chronotropic effects on the cardiovascular system. Its cardiovascular side effects are rare and include palpitations, tachyarrhythmias, cardiomyopathy, angina, and heart failure. We report the case of a 71-year-old female who presented with sudden onset chest pain. Her only outpatient medications included anagrelide and aspirin. She was found to have supraventricular tachycardia (SVT) with aberrancy that responded to beta-blockers. The chest X-ray, computed tomography angiogram (CTA), and echocardiogram were unremarkable. Her arrhythmia may be attributed to the anagrelide in the absence of any cardiovascular findings.
format Online
Article
Text
id pubmed-9213328
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-92133282022-06-22 Anagrelide-Induced Supraventricular Tachycardia: A Case Report Badar, Faraz Azeez, Hayder Abdulrahman, Zeinab Ashraf, Aqsa Iftikhar, Asma Cureus Internal Medicine Anagrelide is an inhibitor of the phosphodiesterase-3 (PDE-3) enzyme that suppresses megakaryocytes; hence it is used in the treatment of essential thrombocythemia. Anagrelide can cause positive inotropic and chronotropic effects on the cardiovascular system. Its cardiovascular side effects are rare and include palpitations, tachyarrhythmias, cardiomyopathy, angina, and heart failure. We report the case of a 71-year-old female who presented with sudden onset chest pain. Her only outpatient medications included anagrelide and aspirin. She was found to have supraventricular tachycardia (SVT) with aberrancy that responded to beta-blockers. The chest X-ray, computed tomography angiogram (CTA), and echocardiogram were unremarkable. Her arrhythmia may be attributed to the anagrelide in the absence of any cardiovascular findings. Cureus 2022-06-20 /pmc/articles/PMC9213328/ /pubmed/35747119 http://dx.doi.org/10.7759/cureus.26119 Text en Copyright © 2022, Badar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Badar, Faraz
Azeez, Hayder
Abdulrahman, Zeinab
Ashraf, Aqsa
Iftikhar, Asma
Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title_full Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title_fullStr Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title_full_unstemmed Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title_short Anagrelide-Induced Supraventricular Tachycardia: A Case Report
title_sort anagrelide-induced supraventricular tachycardia: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213328/
https://www.ncbi.nlm.nih.gov/pubmed/35747119
http://dx.doi.org/10.7759/cureus.26119
work_keys_str_mv AT badarfaraz anagrelideinducedsupraventriculartachycardiaacasereport
AT azeezhayder anagrelideinducedsupraventriculartachycardiaacasereport
AT abdulrahmanzeinab anagrelideinducedsupraventriculartachycardiaacasereport
AT ashrafaqsa anagrelideinducedsupraventriculartachycardiaacasereport
AT iftikharasma anagrelideinducedsupraventriculartachycardiaacasereport