MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Retinoblastoma is a rare, intraocular paediatric cancer that originates in the neural retina and is most frequently caused by bi-allelic loss of RB1 gene function. Other oncogenic mutations, such as amplification and increased expression of the MYCN gene, have been found even with proficient RB1 fun...

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Detalles Bibliográficos
Autores principales: Blixt, Maria K. E., Hellsand, Minas, Konjusha, Dardan, Zhang, Hanzhao, Stenfelt, Sonya, Åkesson, Mikael, Rafati, Nima, Tararuk, Tatsiana, Stålhammar, Gustav, All-Eriksson, Charlotta, Ring, Henrik, Hallböök, Finn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213451/
https://www.ncbi.nlm.nih.gov/pubmed/35729105
http://dx.doi.org/10.1038/s41389-022-00409-3

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