Innate immune responses against the fungal pathogen Candida auris

Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be inve...

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Autores principales: Wang, Yuanyuan, Zou, Yun, Chen, Xiaoqing, Li, Hao, Yin, Zhe, Zhang, Baocai, Xu, Yongbin, Zhang, Yiquan, Zhang, Rulin, Huang, Xinhua, Yang, Wenhui, Xu, Chaoyue, Jiang, Tong, Tang, Qinyu, Zhou, Zili, Ji, Ying, Liu, Yingqi, Hu, Lingfei, Zhou, Jia, Zhou, Yao, Zhao, Jingjun, Liu, Ningning, Huang, Guanghua, Chang, Haishuang, Fang, Wenxia, Chen, Changbin, Zhou, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213489/
https://www.ncbi.nlm.nih.gov/pubmed/35729111
http://dx.doi.org/10.1038/s41467-022-31201-x
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author Wang, Yuanyuan
Zou, Yun
Chen, Xiaoqing
Li, Hao
Yin, Zhe
Zhang, Baocai
Xu, Yongbin
Zhang, Yiquan
Zhang, Rulin
Huang, Xinhua
Yang, Wenhui
Xu, Chaoyue
Jiang, Tong
Tang, Qinyu
Zhou, Zili
Ji, Ying
Liu, Yingqi
Hu, Lingfei
Zhou, Jia
Zhou, Yao
Zhao, Jingjun
Liu, Ningning
Huang, Guanghua
Chang, Haishuang
Fang, Wenxia
Chen, Changbin
Zhou, Dongsheng
author_facet Wang, Yuanyuan
Zou, Yun
Chen, Xiaoqing
Li, Hao
Yin, Zhe
Zhang, Baocai
Xu, Yongbin
Zhang, Yiquan
Zhang, Rulin
Huang, Xinhua
Yang, Wenhui
Xu, Chaoyue
Jiang, Tong
Tang, Qinyu
Zhou, Zili
Ji, Ying
Liu, Yingqi
Hu, Lingfei
Zhou, Jia
Zhou, Yao
Zhao, Jingjun
Liu, Ningning
Huang, Guanghua
Chang, Haishuang
Fang, Wenxia
Chen, Changbin
Zhou, Dongsheng
author_sort Wang, Yuanyuan
collection PubMed
description Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.
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spelling pubmed-92134892022-06-23 Innate immune responses against the fungal pathogen Candida auris Wang, Yuanyuan Zou, Yun Chen, Xiaoqing Li, Hao Yin, Zhe Zhang, Baocai Xu, Yongbin Zhang, Yiquan Zhang, Rulin Huang, Xinhua Yang, Wenhui Xu, Chaoyue Jiang, Tong Tang, Qinyu Zhou, Zili Ji, Ying Liu, Yingqi Hu, Lingfei Zhou, Jia Zhou, Yao Zhao, Jingjun Liu, Ningning Huang, Guanghua Chang, Haishuang Fang, Wenxia Chen, Changbin Zhou, Dongsheng Nat Commun Article Candida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall. Nature Publishing Group UK 2022-06-21 /pmc/articles/PMC9213489/ /pubmed/35729111 http://dx.doi.org/10.1038/s41467-022-31201-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Yuanyuan
Zou, Yun
Chen, Xiaoqing
Li, Hao
Yin, Zhe
Zhang, Baocai
Xu, Yongbin
Zhang, Yiquan
Zhang, Rulin
Huang, Xinhua
Yang, Wenhui
Xu, Chaoyue
Jiang, Tong
Tang, Qinyu
Zhou, Zili
Ji, Ying
Liu, Yingqi
Hu, Lingfei
Zhou, Jia
Zhou, Yao
Zhao, Jingjun
Liu, Ningning
Huang, Guanghua
Chang, Haishuang
Fang, Wenxia
Chen, Changbin
Zhou, Dongsheng
Innate immune responses against the fungal pathogen Candida auris
title Innate immune responses against the fungal pathogen Candida auris
title_full Innate immune responses against the fungal pathogen Candida auris
title_fullStr Innate immune responses against the fungal pathogen Candida auris
title_full_unstemmed Innate immune responses against the fungal pathogen Candida auris
title_short Innate immune responses against the fungal pathogen Candida auris
title_sort innate immune responses against the fungal pathogen candida auris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213489/
https://www.ncbi.nlm.nih.gov/pubmed/35729111
http://dx.doi.org/10.1038/s41467-022-31201-x
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