Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters

Colistin is the last-line antibiotic against Gram-negative pathogens. Here we identify an FDA-approved drug, Otilonium bromide (Ob), which restores the activity of colistin against colistin-resistant Gram-negative bacteria in vitro and in a mouse infection model. Ob also reduces the colistin dosage...

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Detalles Bibliográficos
Autores principales: Xu, Chen, Liu, Chenyu, Chen, Kaichao, Zeng, Ping, Chan, Edward Wai Chi, Chen, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213495/
https://www.ncbi.nlm.nih.gov/pubmed/35729200
http://dx.doi.org/10.1038/s42003-022-03561-z

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