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Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2

BRCA1 and BRCA2 are tumour suppressor genes that play a critical role in maintaining genomic stability via the DNA repair mechanism. DNA repair defects caused by BRCA1 and BRCA2 missense variants increase the risk of developing breast and ovarian cancers. Accurate identification of these variants be...

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Detalles Bibliográficos
Autores principales:	Aljarf, Raghad, Shen, Mengyuan, Pires, Douglas E. V., Ascher, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213547/ https://www.ncbi.nlm.nih.gov/pubmed/35729312 http://dx.doi.org/10.1038/s41598-022-13508-3

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