Cargando…

Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity

Autophagy is a catabolic process to eliminate defective cellular molecules via lysosome-mediated degradation. Dysfunctional autophagy is associated with accelerated aging, whereas stimulation of autophagy could have potent anti-aging effects. We report that cannabidiol (CBD), a natural compound from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhizhen, Zheng, Peng, Chen, Xi, Xie, Yuanyi, Weston-Green, Katrina, Solowij, Nadia, Chew, Yee Lian, Huang, Xu-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213613/ https://www.ncbi.nlm.nih.gov/pubmed/35445360 http://dx.doi.org/10.1007/s11357-022-00559-7

Ejemplares similares

PM367. Effect of cannabidiol on cognition in a maternal immune activation (poly IC) model of schizophrenia
por: Osborne, Ashleigh L., et al.
Publicado: (2016)

Inhibition of neuronal autophagy mediates longevity
por: Byrne, Jonathan, et al.
Publicado: (2017)

The Endocannabinoid System and Cannabidiol's Promise for the Treatment of Substance Use Disorder
por: Chye, Yann, et al.
Publicado: (2019)

A protocol for the delivery of cannabidiol (CBD) and combined CBD and ∆(9)-tetrahydrocannabinol (THC) by vaporisation
por: Solowij, Nadia, et al.
Publicado: (2014)

Irisin enhances longevity by boosting SIRT1, AMPK, autophagy and telomerase
por: Sánchez, Begoña, et al.
Publicado: (2022)

WIPI-Mediated Autophagy and Longevity
por: Grimmel, Mona, et al.
Publicado: (2015)

Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users
por: Beale, Camilla, et al.
Publicado: (2018)

The effects of preventative cannabidiol in a male neuregulin 1 mouse model of schizophrenia
por: Visini, Gabriela, et al.
Publicado: (2022)

Autophagy and Longevity
por: Nakamura, Shuhei, et al.
Publicado: (2018)

Autophagy-mediated longevity is modulated by lipoprotein biogenesis
por: Seah, Nicole E., et al.
Publicado: (2015)

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice
por: Zheng, Shuqiu, et al.
Publicado: (2010)

Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage
por: Shao, Jiaxiang, et al.
Publicado: (2016)

Association of SIRT6 Gene Polymorphisms with Human Longevity
por: LI, You, et al.
Publicado: (2016)

Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy
por: Böckmann, Sabine, et al.
Publicado: (2020)

Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review
por: Fu, Ze, et al.
Publicado: (2023)

Autophagy and longevity: Evolutionary hints from hyper-longevous mammals
por: Locatelli, Andrea G., et al.
Publicado: (2022)

Erratum to: Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage
por: Shao, Jiaxiang, et al.
Publicado: (2017)

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways
por: Kang, Shaolei, et al.
Publicado: (2021)

SIRT3 Enhances Mesenchymal Stem Cell Longevity and Differentiation
por: Denu, Ryan A.
Publicado: (2017)

Phosphatidylethanolamine positively regulates autophagy and longevity
por: Rockenfeller, P, et al.
Publicado: (2015)

Oxidative Stress and Autophagy in Metabolism and Longevity
por: Vikram, Ajit, et al.
Publicado: (2017)

Cannabidiol activates neuronal Kv7 channels
por: Zhang, Han-Xiong Bear, et al.
Publicado: (2022)

Common variants in SIRT1 and human longevity in a Chinese population
por: Lin, Rong, et al.
Publicado: (2016)

SIRT1 performs a balancing act on the tight-rope toward longevity
por: Purushotham, Aparna, et al.
Publicado: (2009)

Cannabidiol Protects Dopaminergic Neuronal Cells from Cadmium
por: Branca, Jacopo Junio Valerio, et al.
Publicado: (2019)

Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity
por: Drummond-Main, Christopher D., et al.
Publicado: (2023)

MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans
por: Jung, Yoonji, et al.
Publicado: (2021)

Impaired mitophagosome–lysosome fusion mediates olanzapine‐induced aging
por: Chen, Xi, et al.
Publicado: (2023)

Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users: A Pragmatic Open-Label Clinical Trial
por: Solowij, Nadia, et al.
Publicado: (2018)

SIRT5‐mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer
por: Shi, Liang, et al.
Publicado: (2018)

Neuronal Inputs and Outputs of Aging and Longevity
por: Alcedo, Joy, et al.
Publicado: (2013)

Neuronal regulation of longevity by staying cool
por: Lin, Chih-Chun J., et al.
Publicado: (2018)

Dopaminergic neurons: linking longevity with reproduction?
por: Tian, Xiaolin
Publicado: (2022)

SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men
por: Hirvonen, Katariina, et al.
Publicado: (2017)

Cannabidiol induces autophagy via ERK1/2 activation in neural cells
por: Vrechi, Talita A. M., et al.
Publicado: (2021)

Sitagliptin mitigates hypoxia/reoxygenation (H/R)-induced injury in cardiomyocytes by mediating sirtuin 3 (SIRT3) and autophagy
por: Yang, Mao, et al.
Publicado: (2022)

Photoprotective Effects of Cannabidiol against Ultraviolet-B-Induced DNA Damage and Autophagy in Human Keratinocyte Cells and Mouse Skin Tissue
por: Li, Yanmei, et al.
Publicado: (2022)

SIRT1 is downregulated by autophagy in senescence and aging
por: Xu, Caiyue, et al.
Publicado: (2020)

SIRT1 and Autophagy: Implications in Endocrine Disorders
por: Kim, Ji Yong, et al.
Publicado: (2022)

Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy
por: Romeo-Guitart, David, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2l3sehgo2sl28hogj2v282b0mm