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Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT
PURPOSE: To determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking. MATERIALS AND METHODS: The study included 98 daily CT scans of 35 LAPC pati...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213731/ https://www.ncbi.nlm.nih.gov/pubmed/35756687 http://dx.doi.org/10.3389/fonc.2022.910792 |
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author | Magallon-Baro, Alba Milder, Maaike T. W. Granton, Patrick V. den Toom, Wilhelm Nuyttens, Joost J. Hoogeman, Mischa S. |
author_facet | Magallon-Baro, Alba Milder, Maaike T. W. Granton, Patrick V. den Toom, Wilhelm Nuyttens, Joost J. Hoogeman, Mischa S. |
author_sort | Magallon-Baro, Alba |
collection | PubMed |
description | PURPOSE: To determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking. MATERIALS AND METHODS: The study included 98 daily CT scans of 35 LAPC patients. All scans were manually contoured (MAN), and included the PTV and main organs-at-risk (OAR): stomach, duodenum and bowel. Precision and MIM deformable image registration (DIR) methods followed by contour propagation were used to generate autocontour sets on the daily CT scans. Autocontours remained unedited, and were compared to MAN on the whole organs and at 3, 1 and 0.5 cm from the PTV. Manual and autocontoured OAR were used to generate daily plans using the VOLO™ optimizer, and were compared to non-adapted plans. Resulting planned doses were compared based on PTV coverage and OAR dose-constraints. RESULTS: Overall, both algorithms reported a high agreement between unclipped MAN and autocontours, but showed worse results when being evaluated on the clipped structures at 1 cm and 0.5 cm from the PTV. Replanning with unedited autocontours resulted in better OAR sparing than non-adapted plans for 95% and 84% plans optimized using Precision and MIM autocontours, respectively, and obeyed OAR constraints in 64% and 56% of replans. CONCLUSION: For the majority of fractions, manual correction of autocontours could be avoided or be limited to the region closest to the PTV. This practice could further reduce the overall timings of adaptive radiotherapy workflows for patients with LAPC. |
format | Online Article Text |
id | pubmed-9213731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92137312022-06-23 Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT Magallon-Baro, Alba Milder, Maaike T. W. Granton, Patrick V. den Toom, Wilhelm Nuyttens, Joost J. Hoogeman, Mischa S. Front Oncol Oncology PURPOSE: To determine the dosimetric impact of using unedited autocontours in daily plan adaptation of patients with locally advanced pancreatic cancer (LAPC) treated with stereotactic body radiotherapy using tumor tracking. MATERIALS AND METHODS: The study included 98 daily CT scans of 35 LAPC patients. All scans were manually contoured (MAN), and included the PTV and main organs-at-risk (OAR): stomach, duodenum and bowel. Precision and MIM deformable image registration (DIR) methods followed by contour propagation were used to generate autocontour sets on the daily CT scans. Autocontours remained unedited, and were compared to MAN on the whole organs and at 3, 1 and 0.5 cm from the PTV. Manual and autocontoured OAR were used to generate daily plans using the VOLO™ optimizer, and were compared to non-adapted plans. Resulting planned doses were compared based on PTV coverage and OAR dose-constraints. RESULTS: Overall, both algorithms reported a high agreement between unclipped MAN and autocontours, but showed worse results when being evaluated on the clipped structures at 1 cm and 0.5 cm from the PTV. Replanning with unedited autocontours resulted in better OAR sparing than non-adapted plans for 95% and 84% plans optimized using Precision and MIM autocontours, respectively, and obeyed OAR constraints in 64% and 56% of replans. CONCLUSION: For the majority of fractions, manual correction of autocontours could be avoided or be limited to the region closest to the PTV. This practice could further reduce the overall timings of adaptive radiotherapy workflows for patients with LAPC. Frontiers Media S.A. 2022-06-08 /pmc/articles/PMC9213731/ /pubmed/35756687 http://dx.doi.org/10.3389/fonc.2022.910792 Text en Copyright © 2022 Magallon-Baro, Milder, Granton, Toom, Nuyttens and Hoogeman https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Magallon-Baro, Alba Milder, Maaike T. W. Granton, Patrick V. den Toom, Wilhelm Nuyttens, Joost J. Hoogeman, Mischa S. Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title | Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title_full | Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title_fullStr | Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title_full_unstemmed | Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title_short | Impact of Using Unedited CT-Based DIR-Propagated Autocontours on Online ART for Pancreatic SBRT |
title_sort | impact of using unedited ct-based dir-propagated autocontours on online art for pancreatic sbrt |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213731/ https://www.ncbi.nlm.nih.gov/pubmed/35756687 http://dx.doi.org/10.3389/fonc.2022.910792 |
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